Evidence map›Paper›PMID 41310313›Full record

ReviewCurrent urology reports2025

Testosterone and Lower Urinary Tract Symptoms: A Narrative Review.

Colin J O'Mahony, M A Arshad, S M Norton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current urology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Colin J O'MahonyDepartment of Urology, University Hospital Limerick, Dooradoyle, Limerick, Ireland. colinjomahony@gmail.com.
M A ArshadDepartment of Urology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
S M NortonDepartment of Urology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo examine current evidence on the relationship between testosterone and lower urinary tract symptoms (LUTS) in men, focusing on endocrine, metabolic, and inflammatory mechanisms and their implications for clinical practice. RECENT

findingsRecent studies demonstrate that testosterone influences bladder, prostate, and pelvic floor function through androgen-receptor pathways. Low testosterone amplifies inflammation, oxidative stress, and vascular dysfunction, while metabolic syndrome with associated hypogonadism and sleep disorders exacerbate LUTS severity. Experimental and clinical data confirm that physiologic testosterone therapy does not worsen LUTS or prostate outcomes when appropriately monitored. Testosterone deficiency contributes to LUTS through systemic, not purely anatomical, mechanisms. Restoring physiologic hormone balance and addressing metabolic and sleep factors improves urinary function and quality of life. Future research should prioritise phenotype-specific trials and integrated metabolic-endocrine-urological approaches to refine personalised care for men with LUTS and hypogonadism.

Indexed as

Lower Urinary Tract SymptomsTestosteroneHumansHypogonadismMaleTestosteroneBenign prostatic hyperplasiaHypogonadismInflammationLower urinary tract symptomsMetabolic syndromeTestosterone

Identifiers

PMID41310313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.