ReviewNature reviews. Chemistry2026
Unsymmetric bimetallic centres in metalloproteins and synthetic models.
Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A binuclear copper enzyme platform for enantioconvergent radical (pseudo)halogenation.bioRxiv : the preprint server for biology · 2026Article
- Asymmetric Oxygen Bridges: A Unified Design Framework for Enhanced Catalysis.Advanced materials (Deerfield Beach, Fla.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many biological bimetallic active sites exhibit unsymmetric coordination environments, allowing the two metal centres to perform distinct catalytic roles. By contrast, most synthetic homogeneous catalysts rely on symmetric ligand frameworks for ease of synthesis. This represents a considerable divergence between natural and synthetic catalysts, leaving the functional importance of unsymmetric arrangement largely underexplored. In this Review, we highlight biological examples of unsymmetric bimetallic centres and their roles in catalysis. We examine how the inherent lack of symmetry - achieved through ligand differentiation or heterobimetallic design - has been used to mimic nature's bimetallic sites. We also discuss recent advances that show how an unsymmetric environment can lower the barriers of bond activation and outline current challenges in probing the function of unsymmetric features, along with strategies to overcome them.
Indexed as
Identifiers
41310298What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.