ArticlePlant cell reports2025
Glyceraldehyde-3-phosphate dehydrogenase 7 (FtGAPDH7) confers heat stress tolerance in buckwheat [Fagopyrum tataricum (L.) Gaertn].
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
key messageA total of 13 FtGAPDHs was identified in buckwheat and FtGAPDH7 plays a key role in heat stress response. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway that helps in the production of energy in living cells. GAPDH is a multifunctional enzyme that performs several roles including participation in plant growth and development, enhancing resilience to biotic and abiotic stress, and safeguarding genome integrity. In the present study, a total of 13 GAPDH genes were identified across the eight chromosomes in buckwheat [Fagopyrum tataricum (Ft)], comprising eleven GAPDH genes and two GAPN genes. The cis-regulatory element analysis elucidated that the FtGAPDH genes may regulate diverse biological processes and exhibit responses against various biotic and abiotic stressors. FtGAPDH gene expression analysis was conducted in different abiotic stresses, including heat, cold, salt, and drought stress, to comprehend the functions of these genes in mediating abiotic stress responses. In cold stress, FtGAPDH8/10 and 11 showed significant upregulation by 13.6-fold, 4.8-fold, and 25.3-fold, respectively. Under drought stress, significant downregulation was observed in FtGAPDH6/8 and 9. Similarly, salt stress led to the downregulation of maximum genes, and FtGAPDH1/2/10 and 11 showed significant downregulation. Under heat stress, FtGAPDH2/3/6/7/9/10 and 11 exhibited significant upregulation, with the most pronounced increase observed in FtGAPDH7, which was upregulated up to 66-fold. Furthermore, the overexpression of FtGAPDH7 in buckwheat and in Nicotiana benthamiana resulted in higher chlorophyll content, Fv/Fm and reduced malondialdehyde (MDA) and electrolyte leakage levels under heat stress as compared to the wild type, indicating enhanced photosynthetic efficiency and reduced oxidative damage, which provides evidence that this gene might be involved in thermotolerance. This study highlights the potential roles of FtGAPDH7 genes in heat stress responses, providing a foundation for their functional validation to understand the regulatory mechanism and eventually to develop heat stress-tolerant buckwheat cultivars.
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