ArticleLangenbeck's archives of surgery2025
Association between adjuvant chemotherapy and risk of incisional hernia after colorectal cancer resection - a single-centre cohort study.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Standardised Pfannenstiel versus supraumbilical muscle-sparing transverse extraction sites in colon cancer surgery: An IDEAL stage 4 report.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aimed to determine whether adjuvant chemotherapy after colorectal cancer resection is associated with an increased risk of developing incisional hernia (IH).
methodsAll patients undergoing elective curative resection of stage I-III colon adenocarcinoma between 2014 and 2017 at Copenhagen University Hospital - North Zealand were registered in a local database prospectively. This study collected additional data from patients' electronic health records (EHR) on chemotherapy and incision placement. The follow-up computed tomography scans were retrospectively reassessed by two trained surgeons for incisional hernia for up to five years. Patients were stratified into two groups: those receiving adjuvant chemotherapy (study group) and those not receiving it (control group). The primary outcome was CT-verified IH.
resultsOf 451 patients, 303 were included in the final analysis, with 108 in the chemotherapy group and 195 in the control group. The study found that the unadjusted risk of IH was 28.9% (95% CI: 20.4-37.4) in the chemotherapy group and 21.1% (95% CI: 15.4-26.9) in the control group with an absolute risk difference of 7.7% (95% CI: -2.3-17.9, p = 0.13). After inverse probability of treatment weighting, the absolute risk difference was 5.6% (95% CI: -4.2-15.6), p = 0.26).
conclusionsAdjuvant chemotherapy after colon cancer resection does not seem to be associated with a significantly higher risk of IH.
trial registrationDanish Patient Safety Authority (#31-1522-51).
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