Evidence map›Paper›PMID 41310233›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Association between oral management and complications after hematopoietic stem cell transplantation.

Noyuri Yamaji, Kojiro Morita, Sachiko Ono, Miho Ishimaru, Shotaro Aso, Nobuyuki Yotani, Mari Ikeda, Sachiko Kita, Mayumi Morisaki-Nakamura, Norihiko Inoue and 5 more

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Noyuri YamajiInstitute of Clinical Epidemiology, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan. yamaji.n@med.showa-u.ac.jp.ORCID http://orcid.org/0000-0002-4212-6723
Kojiro MoritaDepartment of Nursing Administration and Advanced Clinical Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2306-0669
Sachiko OnoDepartment of Eat-Loss Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4378-2578
Miho IshimaruDepartment of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5269-5698
Shotaro AsoDepartment of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7804-2433
Nobuyuki YotaniDepartment of Palliative Medicine, National Center for Child Health and Development, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4874-3738
Mari IkedaDepartment of Family Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2000-8523
Sachiko KitaInstitute of Trauma Recovery, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3348-6364
Mayumi Morisaki-NakamuraDepartment of Family Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0216-0991
Norihiko InoueInstitute of Clinical Epidemiology, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.ORCID http://orcid.org/0000-0001-9187-371X
Takashi YoshiokaInstitute of Clinical Epidemiology, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.ORCID http://orcid.org/0000-0001-7709-8278
Takeshi HasegawaInstitute of Clinical Epidemiology, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.ORCID http://orcid.org/0000-0003-0420-5583
Hiroki MatsuiDepartment of Clinical Epidemiology and Health Economics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0004-4743
Kiyohide FushimiDepartment of Health Policy and Informatics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1894-0290
Hideo YasunagaDepartment of Clinical Epidemiology and Health Economics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6017-469X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHematopoietic stem cell transplantation (HSCT) is associated with oral mucositis and infections due to intensive conditioning and immunosuppression. Although pretransplant oral management is recommended, its effectiveness remains unclear. This study examined the association between oral management by dentists before HSCT and the duration of severe oral mucositis, infections, and mortality using a nationwide inpatient database in Japan.

methodsWe conducted a retrospective cohort study using the Diagnosis Procedure Combination database. Patients who underwent HSCT between May 2018 and February 2022 were divided into two groups: those who received oral management by dentists before HSCT and those who did not. After 1:1 propensity score matching, we compared the duration of severe oral mucositis (defined as opioid use within 30 days after HSCT), infections (defined as concurrent use of antibiotics and blood cultures within 30 days after HSCT), and 30-day in-hospital mortality between the groups.

resultsAmong the 15,911 eligible patients (mean age 49.0 ± 17.6 years), 5546 (34.9%) received pre-HSCT oral management. Propensity score matching yielded 4945 pairs. No significant differences were observed in the duration of severe oral mucositis or in-hospital mortality between groups. However, the patients receiving oral management had a lower incidence of infection than those without oral management (55.1 vs. 59.5%; risk difference, -4.4; 95% confidence interval, -6.4 to -2.5).

conclusionPre-HSCT oral management by dentists may not reduce the duration of severe oral mucositis or all-cause mortality, but may reduce post-transplant infections. Further studies are warranted to clarify the components of oral management that most effectively affect oral mucositis and mortality.

Indexed as

Hematopoietic Stem Cell TransplantationStomatitisAdultAgedDatabases, FactualFemaleHospital MortalityHumansJapanMaleMiddle AgedPropensity ScoreRetrospective StudiesTransplantation ConditioningHematopoietic stem cell transplantationInfectionOpioidsOral managementOral mucositisPropensity score matching

Identifiers

PMID41310233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.