ArticleThe Journal of antibiotics2026
New indole diketopiperazine from the fungus Penicillium chrysogenum.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
A new indole diketopiperazine penichrysogenone A (1), and two new natural products 4-(N-benzoyl-N-hydroxyamino)-butyric acid (2) and 2-acetamido-N-benzyl-2-(ethylamino)acetamide (3), together with 10 known compounds (4-13) were isolated from the fungus Penicillium chrysogenum wis54-1255. The structure of new compound was determined by the extensive spectroscopic analyses and ECD calculations. Bioactivity assays revealed that compound 4 showed antibacterial activity against Pseudomonas solanacearum (MIC = 64 μg/mL), while compound 10 exhibited antifungal activity against Candida auris (MIC = 32 μg/mL). Furthermore, compounds 2 and 10 displayed potent ABTS radical scavenging activity, superior to that of the positive control ascorbic acid.
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Registered trials
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