Evidence map›Paper›PMID 41310222›Full record

Observational studyPediatric research2026

Hemodynamic adaptation in neonates with early-onset severe anemia during transition period.

Yiyong Fu, Biao Li, Jingyi Zhang, Xiaohong Luo, Huaying Li, Xiaofeng Zhou, Linping Zhong, Lin Zhu, Gaoyang Qin, Xiaolong Zhang and 6 more

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yiyong Fu *Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Biao Li *Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jingyi Zhang *Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaohong LuoDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Huaying LiDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaofeng ZhouDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Linping ZhongDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lin ZhuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Gaoyang QinDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaolong ZhangDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Minsheng ZhengDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Youning HuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shuqiang GaoDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xuhong HuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Rong JuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. jurong@uestc.edu.cn.
Tiantian XiaoDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. xiaott@uestc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo characterize hemodynamics in the first 24 h after birth in neonates with severe anemia.

methodThis was a retrospective analysis of data from a prospective cohort from our critically ill neonate database, that included neonates with severe anemia from December 2022 to June 2024. The results obtained from neonates with severe anemia and the control group were compared.

resultsA total of 21 neonates born at 37 [35.00, 38.00] weeks and weighing 2780 [2350, 3200] grams were included. Compared with the control group, we observed lower peak systolic myocardial velocity in biventricular (left: 5.67 [5.43, 6.48] vs. 6.6 [6.12, 7.32], p < 0.001; right: 6.33 [5.72, 7.48] vs. 8.02 [6.74, 8.86], p < 0.001). A greater ratio of the tricuspid valve early inflow velocity/early diastolic myocardial velocity was noted (6.63 [5.92, 9.27] vs. 5.31 [4.67, 6.55], p < 0.001). The peak systolic blood flow of middle cerebral arteries was greater (left: 55.90 [47.10, 64.90] vs. 44.95 [38.20, 50.95], p = 0.008; right: 52.00 [40.88, 56.15] vs. 45.20 [38.00, 52.00], p = 0.048). The lung ultrasound score was 18.00 [13.5, 25.5].

conclusionNeonates with severe anemia are characterized by reduced cardiac systolic function, reduced right diastolic function, increased cerebral blood flow, and pulmonary edema during the transition period. CLINICAL

trial registrationThe study was registered in Chinese Clinical Trial Registry (ChiCTR2200065581; https://www.chictr.org.cn/com/25/showproj.aspx?proj=184095 ). IMPACT: This study explored hemodynamic characteristics, including cardiac function, blood flow in middle cerebral arteries, and the lung air/fluid ratio, in neonates with early-onset severe anemia and emphasized impaired cardiac systolic and diastolic function and a hypervolemic state in the pulmonary system and brain during the transition period. These hemodynamic changes are more related to the duration of severe anemia than to the severity of anemia. Given the hemodynamic changes in neonates with severe anemia, volume expansion and transfusion should be optimized.

Indexed as

Adaptation, PhysiologicalAnemiaHemodynamicsBlood Flow VelocityFemaleHumansInfant, NewbornMaleProspective StudiesRetrospective Studies

Identifiers

PMID41310222

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.