ArticleNPJ digital medicine2025
A multi-criterion feature integration framework for accurate diagnosis of Sjögren's disease using routine laboratory tests.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06982482 (Artificial Intelligence Based Models for Primary Sjögren's Syndrome Diagnosis Using Laboratory Data), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Artificial Intelligence Based Models for Primary Sjögren's Syndrome Diagnosis Using Laboratory Data: A Chinese Multicenter Retrospective Study
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9 authors.
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Abstract
Sjögren's disease (SjD) is a common systemic autoimmune disease that remains difficult to diagnose early due to non-specific symptoms and lack of definitive biomarkers. This multicentre retrospective cohort study analysed data from 34,958 patients across three hospitals in China to assess the diagnostic potential of routine laboratory tests and to develop a robust, low-cost artificial intelligence model, the Sjögren Multi-criterion Feature Integration Framework (SMFIF). This study is registered with ClinicalTrials.gov (NCT06982482). The model was built using 16 optimal features selected through ensemble learning and SHAP analysis, and validated internally (n = 9329) and externally (n = 545). SMFIF achieved high diagnostic performance, with AUCs of 0.929, 0.934, and 0.964 in testing, internal, and external validation sets, respectively, outperforming conventional biomarkers such as anti-SSA/Ro and ANA. Calibration curves and confusion matrices confirmed its reliability. SMFIF is publicly available and provides probabilities of SjD based on laboratory data, offering a practical diagnostic tool for clinical use.
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