Evidence map›Paper›PMID 41310214›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Development of risk scoring system for adjacent vertebral fractures after percutaneous vertebroplasty.

Xiao-Yong Ge, Ying-Jie Wang, Shu-Bao Zhang, Chang-Xu Ren, Jin Yang, Ke Xu, Shan-Jin Wang

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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-Yong Ge *Department of Osteoporosis and Bone Diseases, Pudong New Area Geriatric Hospital, Shanghai, China.
Ying-Jie Wang *Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shu-Bao ZhangDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Chang-Xu RenDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jin YangDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ke XuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shan-Jin WangDepartment of Osteoporosis and Bone Diseases, Pudong New Area Geriatric Hospital, Shanghai, China. kingspine@163.com.

Funding

Joint research project of Health Science and Technology project of Shanghai Pudong New Area Health Commission PW2023D-12Specialty Feature Construction Project of Shanghai Pudong New Area Health Commission PWZzb2022-22
6 · The paper itself

Abstract

purposePatients undergoing percutaneous vertebroplasty (PVP) are at a significant risk of developing adjacent vertebral fractures (AVF) following osteoporotic vertebral fractures (OVFs). Therefore, establishing a risk scoring system for AVF is crucial for timely intervention. MATERIALS AND

methodsPatients who underwent PVP for OVFs at our hospital from June 2016 to August 2022 were retrospectively included, with cases from June 2016 to May 2021 used for model training and June 2021 to August 2022 for validation. Patients were divided into AVF and non-refracture (NRF) groups according to whether AVF occurred after treated within 24 months in both cohorts. Potential predictors were compared, and independent risk factors were identified using multivariate logistic and LASSO regression. A risk scoring system was developed and evaluated for discrimination (ROC curve), calibration, and clinical utility (DCA).

resultsA total of 456 patients were included, with 364 in the training cohort (52 in AVF and 312 in NRF) and 92 in the validation cohort (11 AVF, 81 NRF). Multivariate logistic regression and LASSO regression identified age, T-score, paraspinal fat infiltration (FI), intervertebral disc degeneration (IDD), upper endplate fracture, and bone cement leakage as key predictors for AVF. A risk score system (0–12 points) was developed based on these factors. ROC analysis and calibration curve indicated this scoring system has good discriminatory ability (AUC: 0.874) and goodness-of-fit in the training cohort. At a threshold of ≥ 7 points, the system achieved 88.5% sensitivity and 73.4% specificity. In the validation cohort, this scoring system retained strong discrimination (AUC: 0.826) and good calibration. DCA demonstrated a good clinical net benefit within the probability threshold range of 0.01 to 0.48 in both cohorts.

conclusionThis scoring system shows good clinical performance. An intraoperative score ≥ 7 indicates high AVF risk, while preoperative scores ≥ 6 warrant careful bone cement injection to minimize cement leakage.

Indexed as

Osteoporotic FracturesPostoperative ComplicationsSpinal FracturesVertebroplastyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsAdjacent vertebraeOlder adultOsteoporosisPercutaneous vertebroplastyPredictorScore systemVertebral fracture

Identifiers

PMID41310214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.