Evidence map›Paper›PMID 41310206›Full record

ArticleNPJ digital medicine2025

Benchmarking proprietary and open-source language and vision-language models for gastroenterology clinical reasoning.

Seyed Amir Ahmad Safavi-Naini, Shuhaib Ali, Omer Shahab, Zahra Shahhoseini, Thomas Savage, Sara Rafiee, Jamil S Samaan, Reem Al Shabeeb, Farah Ladak, Jamie O Yang and 8 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Seyed Amir Ahmad Safavi-Naini *Division of Data-Driven and Digital Health (D3M), The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shuhaib Ali *University of Texas Health, Department of Medicine, Division of Gastroenterology and Hepatology, San Antonio, TX, USA.
Omer Shahab *Division of Gastroenterology, Virginia Hospital Center, Arlington, VA, USA.
Zahra ShahhoseiniSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Thomas SavageDepartment of Medicine, Stanford University, Stanford, CA, USA.
Sara RafieeSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jamil S SamaanKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Reem Al ShabeebDepartment of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, USA.
Farah LadakUniversity of Texas Health, Department of Medicine, Division of Gastroenterology and Hepatology, San Antonio, TX, USA.
Jamie O YangDepartment of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Juan EchavarriaUniversity of Texas Health, Department of Medicine, Division of Gastroenterology and Hepatology, San Antonio, TX, USA.
Sumbal BabarDivision of Infectious Diseases, Department of Medicine, University of Texas Health, San Antonio, TX, USA.
Aasma ShaukatDivision of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Samuel MargolisDavid Geffen School Medicine, University of California, Los Angeles, CA, USA.
Nicholas P TatonettiDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA.
Girish NadkarniDivision of Data-Driven and Digital Health (D3M), The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bara El KurdiUniversity of Texas Health, Department of Medicine, Division of Gastroenterology and Hepatology, San Antonio, TX, USA. baraabayern@gmail.com.
Ali SoroushDivision of Data-Driven and Digital Health (D3M), The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Ali.Soroush@mountsinai.org.

Funding

American Gastroenterological Association AGA2023-32-06
6 · The paper itself

Abstract

This study evaluated the effectiveness of large language models (LLMs) and vision-language models (VLMs) in gastroenterology. We used board-style multiple-choice questions to assess the performance of both proprietary and open-source LLMs and VLMs-including GPT, Claude, Gemini, Mistral, Llama, Mixtral, Phi, and Qwen, across different interfaces, computing environments, and levels of compression (quantization). Among the proprietary models, o1-preview (82.0%) and Claude3.5-Sonnet (74.0%) had the highest accuracy, outperforming the top open-source models: Llama3.3-70b (65.7%) and Qwen-2.5-72b (61.0%). Among the small quantized open-source models, the 8-bit Llama 3.2-11b (51.7%) and 6-bit Phi3-14b (48.7%) performed the best, with scores comparable to their full-precision counterparts. Notably, VLM accuracy on image-containing questions improved (~10%) when given human-generated captions, remained unchanged with original images, and declined with LLM-generated captions. Further research is warranted to evaluate model capabilities in real-world clinical decision-making scenarios.

Identifiers

PMID41310206
PMCPMC12749705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.