Evidence map›Paper›PMID 41310198›Full record

ArticleCommunications biology2025

Regulation of membrane protein activity by cyclopropane fatty acids in Escherichia coli lipid environment.

Kazumasa Hori, Shin Hamamoto, Keiko Shinoda, Kazuhiro Nakamura, Ryo Iwama, Tetsuro Ujihara, Saori Kosono, Makoto Nishiyama, Hisashi Kawasaki, Takeo Tomita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kazumasa Hori *Agro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Shin Hamamoto *Agro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. uhamamoto@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-7619-572X
Keiko ShinodaAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Kazuhiro NakamuraAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Ryo IwamaCollaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan.
Tetsuro UjiharaKyowa Hakko Bio Co., Ltd., Tokyo, Japan.
Saori KosonoAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7108-5142
Makoto NishiyamaAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8143-8052
Hisashi KawasakiAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. ukawasaki@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-6662-9301
Takeo TomitaAgro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. uttomita@gmail.com.ORCID http://orcid.org/0000-0002-2168-0215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane proteins are crucial in cellular processes like signal and energy transduction and are influenced by the properties of the surrounding lipid bilayer. Fatty acids, key components of phospholipids, adjust membrane properties in response to environmental changes; however, their direct effect on membrane protein activity is poorly understood. Cyclopropane fatty acids (CFAs) are produced by a cyclopropane fatty acid synthase (Cfa) by adding a methylene group to unsaturated fatty acids. CFAs are abundant in the membranes of Escherichia coli, particularly during the stationary phase or stress conditions, and are believed to contribute to modulating membrane rigidity and permeability, yet their functional role in membrane protein regulation remains unclear. Here, we examined the effect of CFAs on the activity of NhaA, a Na

Indexed as

CyclopropanesEscherichia coliEscherichia coli ProteinsFatty AcidsMembrane ProteinsCell MembraneMethyltransferasesMolecular Dynamics SimulationPhospholipidscyclopropane fatty acidsCyclopropanescyclopropane synthetaseEscherichia coli ProteinsFatty AcidsMembrane ProteinsMethyltransferasesPhospholipids

Identifiers

PMID41310198
PMCPMC12749491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.