Evidence map›Paper›PMID 41310182›Full record

ArticleBone marrow transplantation2026

Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis.

Johanna Richter, Nico Gagelmann, Felix Fischbach, Kristin Rathje, Lena Kristina Pfeffer, Boris Fehse, Anita Badbaran, Susanna Carolina Berger, Rolf Krause, Evgeny Klyuchnikov and 6 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07635693 (ATLG Levels and Immune Reconstitution Kinetics in Autologous HSCT for Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07635693 recruitingnot on this map

ATLG Levels and Immune Reconstitution Kinetics in Autologous HSCT for Multiple Sclerosis

TypeobservationalSponsorCiceri FabioRan2026 to 2029Enrolled20ConditionsMultiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant, ATLGArmsATLG administration
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johanna Richter *Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nico Gagelmann *Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-0891-1744
Felix FischbachInstitute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kristin RathjeDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lena Kristina PfefferInstitute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Boris FehseDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anita BadbaranDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Susanna Carolina BergerDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rolf KrauseDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Evgeny KlyuchnikovDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christine WolschkeDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Catherina LueckDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Francis AyukDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-6297-1847
Manuel A FrieseInstitute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christoph HeesenInstitute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nicolaus KrögerDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. nmkroeger@outlook.de.ORCID 0000-0001-5103-9966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous hematopoietic stem cell transplantation is an effective therapeutic option for patients with treatment-refractory multiple sclerosis (MS) and may be considered as first line treatment in aggressive forms. Currently, a variety of conditioning and serotherapy regimens are employed across transplant centers. In this study, we compared immune reconstitution at days 30 and 100 post-transplant in MS patients undergoing AHSCT with cyclophosphamide-based conditioning, combined with in vivo T-cell depletion using either polyclonal rabbit anti-thymocyte globulin (ATG; Thymoglobulin, Genzyme-Sanofi) or rabbit anti-T-lymphocyte globulin (ATLG; Grafalon, Neovii). We observed a significantly faster immune reconstitution for CD3

Indexed as

Antilymphocyte SerumHematopoietic Stem Cell TransplantationImmune ReconstitutionInfectionsMultiple SclerosisTransplantation ConditioningAdultFemaleHumansMaleMiddle AgedTransplantation, AutologousAntilymphocyte Serumthymoglobulin

Identifiers

PMID41310182
PMCPMC12909108

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