Evidence map›Paper›PMID 41310134›Full record

ArticleNPJ digital medicine2025

Hierarchical reasoning for lung cancer detection: from multi-scale perception to hypergraph inference with CR-YOLO.

Zhengshui Xu, Tianle Shen, Changchun Ye, Yu Li, Danwen Zhao, Ming Zhang, Yao Cheng, Jintao Chai, Jiantao Jiang, Junfeng Xi and 3 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhengshui Xu *Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tianle Shen *Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Changchun YeDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yu LiDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Danwen ZhaoDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ming ZhangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yao ChengDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jintao ChaiDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jiantao JiangDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Junfeng XiDepartment of Thoracic Surgery, First Hospital of Yulin City, Yulin, Shaanxi, China.
Chao XuZhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. xuchao@zjcc.org.cn.
Wei ChenDepartment of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. chenweiuro@wmu.edu.cn.
Shiyuan LiuDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. liushiyuan@xjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate detection of lung cancer from Computed Tomography (CT) scans is vital for improving patient survival but remains challenging for deep learning models, which struggle with scale variations of pulmonary nodules and the complex reasoning required for diagnosis. We propose CR-YOLO, a novel framework incorporating a Cognitive Reasoning C2f (CR-C2f) module that emulates a radiologist's hierarchical workflow. CR-YOLO employs a Multi-scale Convolution (MSC) module for robust feature perception, Global-Local Attention (GLA) Bottlenecks to integrate local morphology with contextual dependencies, and a Hypergraph Convolution (HGC) Refiner for high-order relational inference. Experiments demonstrate that CR-YOLO achieves a mean Average Precision (mAP) of 92.5%, a 4.1% absolute improvement over the YOLOv8n baseline. In addition to improved accuracy, CR-YOLO enhances interpretability through Grad-CAM analysis, highlighting its potential as a reliable and transparent tool for early lung cancer diagnosis.

Identifiers

PMID41310134
PMCPMC12660665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.