ArticleScientific reports2025
Exosomal miR-20a-5p derived from cisplatin-resistant osteosarcoma cells promotes chemoresistance via Inhibition of ferroptosis through targeting RUNX3.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cisplatin resistance continues to pose a significant challenge in the treatment of osteosarcoma, markedly impairing clinical outcomes. Accumulating evidence indicates that exosomal microRNAs (miRNAs) facilitate intercellular communication and play a critical role in drug resistance mechanisms. In this study, we conducted high-throughput sequencing of serum-derived exosomes and identified miR-20a-5p as significantly upregulated in cisplatin-resistant osteosarcoma patients. Functional analyses revealed that exosomes enriched with miR-20a-5p derived from cisplatin-resistant HOS cells (HOS-DDP) were internalized by sensitive HOS cells, thereby promoting cisplatin resistance through the inhibition of ferroptosis. Mechanistically, co-culture with miR-20a-5p - rich exosomes resulted in preserved mitochondrial morphology, reduced Fe
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