Evidence map›Paper›PMID 41309994›Full record

ArticleNPJ digital medicine2025

Understanding the robustness of vision-language models to medical image artefacts.

Zijie Cheng, Ariel Yuhan Ong, Siegfried K Wagner, David A Merle, Lie Ju, Hanyuan Zhang, Ruinian Chen, Linze Pang, Boxuan Li, Tiantian He and 12 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zijie ChengDepartment of Medical Physics & Biomedical Engineering, University College London, London, UK. zijie.cheng.23@ucl.ac.uk.
Ariel Yuhan OngInstitute of Ophthalmology, University College London, London, UK.
Siegfried K WagnerInstitute of Ophthalmology, University College London, London, UK.
David A MerleInstitute of Ophthalmology, University College London, London, UK.
Lie JuInstitute of Ophthalmology, University College London, London, UK.
Hanyuan ZhangDepartment of Medical Physics & Biomedical Engineering, University College London, London, UK.
Ruinian ChenDepartment of Computer Science, University College London, London, UK.
Linze PangSchool of Computer Science and Technology, Beijing Jiaotong University, Beijing, China.
Boxuan LiDepartment of Medical Physics & Biomedical Engineering, University College London, London, UK.
Tiantian HeUCL Hawkes Institute, University College London, London, UK.
Anran RanDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Hongyang JiangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Dawei Gabriel YangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Ke ZouCentre for Innovation and Precision Eye Health; and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jocelyn Hui Lin GohSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Sahana SrinivasanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Andre AltmannDepartment of Medical Physics & Biomedical Engineering, University College London, London, UK.
Daniel C AlexanderUCL Hawkes Institute, University College London, London, UK.
Carol Y CheungDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Pearse A KeaneInstitute of Ophthalmology, University College London, London, UK.
Yukun ZhouInstitute of Ophthalmology, University College London, London, UK. yukun.zhou.19@ucl.ac.uk.

Funding

Wellcome TrustWellcome Trust Early-Career 318987/Z/24/Z
6 · The paper itself

Abstract

Vision-language models (VLMs) show promise for answering clinically relevant questions, but their robustness to medical image artefacts remains unclear. We evaluated VLMs' robustness through their performance on images with and without weak artefacts across five artefact categories, as well as their ability to detect images with strong artefacts. We built evaluation benchmarks using brain MRI scans, Chest X-ray, and retinal images, involving four real-world medical datasets. VLMs achieved moderate accuracy on original unaltered images (0.645, 0.602 and 0.604 for MRI, OCT, and X-ray applications, respectively). Accuracy declined with weak artefacts (-3.34%, -9.06% and -10.46%), while strong artefacts were detected at low rates (0.194, 0.128 and 0.115). Our findings indicated that VLMs are not yet capable of performing tasks on medical images with artefacts, underscoring the need to establish uniform benchmark thoroughly examining model robustness to image artefacts, and explicitly incorporate artefact-aware method design and robustness tests into VLM development.

Identifiers

PMID41309994
PMCPMC12660864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.