Evidence map›Paper›PMID 41309936›Full record

ArticleScientific reports2025

Degenerated meniscus alters knee osteoarthritis-related gene expression in articular chondrocytes through paracrine mechanisms.

Bo Guo, Takashi Kanamoto, Masaharu Aihara, Satoshi Yamakawa, Teruki Yokoyama, Kosuke Ebina, Hiroyuki Tanaka, Ken Nakata

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo GuoDepartment of Health and Sport Sciences, Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Takashi KanamotoDepartment of Health and Sport Sciences, Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan. takanamoto2@gmail.com.
Masaharu AiharaDepartment of Orthopedic Surgery, Aihara Hospital, 3-4-30 Makiochi, Minoh, Osaka, 562-0004, Japan.
Satoshi YamakawaDepartment of Health and Sport Sciences, Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Teruki YokoyamaDepartment of Health and Sport Sciences, Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Kosuke EbinaDepartment of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Hiroyuki TanakaDepartment of Sports Medical Science, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Ken NakataDepartment of Health and Sport Sciences, Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.

Funding

Japan Society for the Promotion of Science JP23K10609Japan Society for the Promotion of Science JP 24K02814
6 · The paper itself

Abstract

The biomechanical properties of the meniscus are involved in the pathogenesis of knee osteoarthritis (KOA), however, the biological role of a degenerated meniscus in KOA is unclear. This study examined the effects of degenerated meniscal tissue on articular chondrocytes using human meniscal tissues and articular chondrocytes obtained from 13 patients with KOA. Co-culture model and supernatant cell culture model were used and RNA sequencing, RT-qPCR and cell immunofluorescence staining were performed. The key finding of this study is that human degenerated meniscus alters expressions of OA-related genes and promotes productions of COX2 and MMP3 proteins in articular chondrocytes from KOA patients through paracrine effect. These findings suggest that degenerated human meniscal tissue induces inflammatory and degenerative changes in articular chondrocytes through a paracrine mechanism, potentially contributing to KOA pathogenesis.

Indexed as

Cartilage, ArticularChondrocytesGene Expression RegulationMeniscusOsteoarthritis, KneeParacrine CommunicationAgedCells, CulturedCoculture TechniquesCyclooxygenase 2FemaleHumansMaleMatrix Metalloproteinase 3Middle AgedCyclooxygenase 2Matrix Metalloproteinase 3MMP3 protein, humanArticular chondrocytesCo-cultureCulture supernatantDegenerated meniscusKnee osteoarthritisParacrine effect

Identifiers

PMID41309936
PMCPMC12770469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.