Evidence map›Paper›PMID 41309868›Full record

ArticleScientific reports2025

Wound healing improvement by a multicomponent wound dressing of keratinocyte-imprinted polydimethylsiloxane substrate in a rabbit model.

Shima Alipour, Davoud Shams, Saeed Samani, Soheila Pourkhodadad, Setayesh Yasami-Khiabani, Sana Banaeianzadeh, Mohammad Mehdi Dehghan, Seyed Mehdi Ghamsari, Morteza Mehrjoo, Fatemeh Alebrahim and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shima Alipour *Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, University of Tehran, P. O. Box: 14199-63114, Tehran, Iran.
Davoud Shams *National Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Saeed SamaniDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, P.O. Box 14176-13151, Tehran, Iran.
Soheila PourkhodadadNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Setayesh Yasami-KhiabaniNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Sana BanaeianzadehDepartment of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, University of Tehran, P. O. Box: 14199-63114, Tehran, Iran.
Mohammad Mehdi DehghanDepartment of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, University of Tehran, P. O. Box: 14199-63114, Tehran, Iran. mdehghan@ut.ac.ir.
Seyed Mehdi GhamsariDepartment of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, University of Tehran, P. O. Box: 14199-63114, Tehran, Iran.
Morteza MehrjooBiomedical Engineering Department, Amirkabir University of Technology (Polytechnic Tehran), P.O Box 15875-4413, Tehran, Iran.
Fatemeh AlebrahimNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Shahram AzariNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Mohammad Ali ShokrgozarNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran.
Shahin BonakdarNational Cell Bank Department, Pasteur Institute of Iran, P.O. Box 13169-43551, Tehran, Iran. shahinbonakdar@yahoo.com.

Funding

Pasteur Institute of Iran 1516
6 · The paper itself

Abstract

Wound healing is a major clinical challenge and regenerative medicine and tissue engineering suggest new ways to overcome such problems. The cell imprinting method can provide cues that regulate cell function or modulate stem cell differentiation into different lineages. In this study, the rabbit keratinocyte-imprinted polydimethylsiloxane (PDMS) substrate (KiPDMS) was made and associated with adipose-derived stem cells (ADSCs), keratinocytes, and collagen scaffold, provided various treatments. After evaluating ADSCs' differentiation into keratinocytes by qPCR and immunocytochemistry techniques, different treatments were implanted in a rabbit ear, histopathological analysis was performed on measuring the epidermal thickness and neovascularization. The histopathological analysis revealed that treated groups increased epidermal thickness (~ 139% up to ~ 998%) and neovascularization (vessel count /mm

Indexed as

BandagesDimethylpolysiloxanesKeratinocytesWound HealingAnimalsCell DifferentiationCollagenDisease Models, AnimalNeovascularization, PhysiologicRabbitsRe-EpithelializationStem CellsTissue EngineeringTissue ScaffoldsbaysilonCollagenDimethylpolysiloxanesCell-imprintingKeratinocyteMesenchymal stem cellPDMSWound dressingWound healing

Identifiers

PMID41309868
PMCPMC12660737

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.