ArticleScientific reports2025
Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
There are limited studies on the relationship between triglyceride glucose-body mass index (TyG-BMI index) and preeclampsia risk in advanced maternal age women. The aim of this study was to investigate the association between TyG-BMI index and the incidence of preeclampsia in advanced maternal age women.This was a retrospective cohort study. A total of 2,296 pregnant women aged ≧ 35 years were included in this study. Multivariate logistic regression analysis was used to assess the association between the TyG-BMI index and preeclampsia, adjusting for potential confounders. Subgroup analyses were conducted to explore the interaction between the TyG-BMI index and parity. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive performance of the TyG-BMI index for preeclampsia.The TyG-BMI index was significantly positively associated with the risk of preeclampsia, demonstrating a dose-response connection. In the fully adjusted model, a one-standard deviation (SD) increase in the TyG-BMI index was associated with a 43% higher risk of preeclampsia (OR = 1.43; 95% CI: 1.25–1.65; P < 0.0001). Subgroup analysis revealed that the association was particularly strong in nulliparous women (OR = 2.21; 95% CI: 1.68–7.14; P < 0.001). The ROC curve analysis demonstrated that the TyG-BMI index had a moderate predictive value for preeclampsia, with an area under the curve (AUC) of 0.724 (95% CI: 0.696–0.756). The TyG-BMI index is significantly associated with an increased risk of preeclampsia in advanced maternal age women, particularly in nulliparous women.
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