ArticleScientific reports2025
The association of depression and oral microbiota.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory biomarkers and oral microbiome alterations in depression and anxiety disorders: a systematic review.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026Pooled it
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- A study on oral microbiome characteristics and differences in epilepsy adults with depressive symptoms based on 16S rRNA sequencing.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The intestinal microbiota has been implicated in depression, and patients with periodontal disease show particularly high rates of depressive symptoms. This study explored the relationship between oral microbiota, depression severity, and systemic inflammatory factors. Thirty-two patients with depression were enrolled and divided into mild (n = 13; PHQ-9 ≤ 14) and major (n = 19; PHQ-9 > 14) depression groups. Significant differences in oral microbial diversity were found between groups. Alpha-diversity was higher in mild depression (Shannon, P = 0.01; Simpson, P = 0.03), although richness did not differ significantly (Chao1, P = 0.06; ACE, P = 0.06). Beta-diversity analysis revealed distinct microbial community structures (Unweighted UniFrac, P < 0.01; Weighted UniFrac, P < 0.01). Several bacterial taxa (e.g., Actinobacteria, Micrococcales, Micrococcaceae, Peptostreptococcaceae, Flavobacteriaceae, Rothia, Paraclostridium, Capnocytophaga, Haemophilus_parainfluenzae, and Neisseria_elongata) showed positive correlations with depression severity. In contrast, Xanthomonadales was negatively associated. No significant intergroup differences were observed in inflammatory factors. These findings suggest that oral microbiota composition and diversity are closely linked to depression severity, though the role of inflammatory factors remains unclear.
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Registered trials
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