Evidence map›Paper›PMID 41309788›Full record

ArticleScientific reports2025

Effect of simulated microgravity via head-down tilt on intracranial compliance, brain oscillations and cardiovascular autonomic modulation.

Rafaella Mendes Zambetta, Étore De Favari Signini, Aparecida Maria Catai, Alberto Benelli, Luca Angius, Thainá Cristina Ramos Dos Santos, Eloisa Soares Michaliski, Leonardo Barcellos de Oliveira, Gabriela Nagai Ocamoto, Emiliano Santarnecchi and 2 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rafaella Mendes ZambettaPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil. rafa.m.zambetta@gmail.com.
Étore De Favari SigniniPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Aparecida Maria CataiPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Alberto BenelliMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Luca AngiusMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Thainá Cristina Ramos Dos SantosPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Eloisa Soares MichaliskiPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Leonardo Barcellos de OliveiraPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Gabriela Nagai OcamotoPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil.
Emiliano SantarnecchiMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gustavo FrigieriBrain4Care Inc, São Carlos, SP, Brazil.
Thiago Luiz RussoPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil. russo@ufscar.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #151218/2023-4Conselho Nacional de Desenvolvimento Científico e Tecnológico #312042/2023-0Fundação de Amparo à Pesquisa do Estado de São Paulo #2016/22215-7Fundação de Amparo à Pesquisa do Estado de São Paulo #2018/25082-3Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/14877-8Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/25569-2Fundação de Amparo à Pesquisa do Estado de São Paulo #2022/09118-3
6 · The paper itself

Abstract

Spaceflight and ground-based models cause fluidshift to the upper part of the body, especially the head. Intracranial compliance (ICC) and cardiovascular autonomic modulation (CAM) can be impacted, impairing cerebral blood flow. ICC is poorly explored but important for astronauts' health. Also, microgravity can reduce brain activity and affect cerebral functions. Fluidshift models are relevant for understanding its effects and the most used one is head-down tilt (HDT). Thus, this study aimed to investigate the immediate effects of HDT at -6º and - 15º on ICC, CAM and brain oscillations in healthy individuals. Sixty-one subjects (22 females) participated in the study (age 32.7 ± 6.2 years). The 30-minute HDT protocol was performed at -6º and - 15º. ICC was assessed non-invasively through the strain gauge sensor, from brain4care system, along with CAM and cortical activity during cognitive and motor tests. Participants had an increase in the ICP P2/P1 ratio when comparing pre and HDT at -6º (p = 0.004) and a trend toward elevation at -15º (p = 0.058). The sympathetic component of CAM was predominant in both HDT, and brain oscillations were reduced in most tests. The study suggests that acute HDT can reduce ICC, altering sympathovagal balance and causing cortical inhibition.

Indexed as

Autonomic Nervous SystemBrainHead-Down TiltWeightlessness SimulationAdultCerebrovascular CirculationFemaleHumansMaleSpace FlightWeightlessnessYoung AdultAutonomic nervous systemCerebral autoregulationCortical electrical activityFluidshiftIntracranial pressureMicrogravity model

Identifiers

PMID41309788
PMCPMC12660767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.