Evidence map›Paper›PMID 41309756›Full record

ArticleScientific reports2025

Inhibiting TRPV4 improves α-synuclein degradation through autophagy-lysosomal pathway in the MPP

Yuncheng Bai, Hui Zang, Zhengbin Chen, Renwan Yin, Wenjing Yang, Jia Luo, Qingjie Ma, Na Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuncheng Bai *Department of Orthopedic Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Hui Zang *Department of Anesthesiology, Kunming City Women and Children Hospital, Kunming, China.
Zhengbin ChenDepartment of Critical Care Medicine, The Second People's Hospital of Baoshan city, Yunnan Province, China.
Renwan YinFaculty of Medical Science, Kunming University of Science and Technology, Kunming, China.
Wenjing YangFaculty of Medical Science, Kunming University of Science and Technology, Kunming, China.
Jia LuoFaculty of Medical Science, Kunming University of Science and Technology, Kunming, China.
Qingjie MaDepartment of Anesthesiology and Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, China. 13888657719@163.com.
Na LiuDepartment of Anesthesiology and Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, China. beautywww2@qq.com.

Funding

The Joint Special Fund of Science and Technology Department of Yunnan Province and Kunming Medical University for Applied Basic Research 202301AY070001-074The National Nature Science Foundation of China 82260236The Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province 202405AC350087
6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder often accompanied by dementia in its advanced stages. The pathogenesis of PD dementia involves abnormal autophagy and the accumulation of phosphorylated at serine 129 α-synuclein (pS129 α-syn). Proper functioning of the autophagy-lysosomal pathway (ALP) is essential for the effective degradation of pS129 α-syn. Our previous studies implicated the calcium channel transient receptor potential vanilloid 4 (TRPV4) in dopaminergic neuron degeneration by demonstrating that its overexpression induces endoplasmic reticulum stress and inflammation, driving neuronal loss-a hallmark of PD. This study aimed to investigate the role of TRPV4 in ALP-mediated pS129 α-syn clearance in the 1-methyl-4-phenylpyridinium ion (MPP

Indexed as

alpha-SynucleinAutophagyLysosomesParkinson DiseaseTRPV Cation Channels1-Methyl-4-phenylpyridiniumAnimalsCell SurvivalPC12 CellsProteolysisRats1-Methyl-4-phenylpyridiniumalpha-SynucleinTrpv4 protein, ratTRPV Cation ChannelsAutophagy-lysosomal pathwayParkinson’s diseaseTRPV4Α-synuclein

Identifiers

PMID41309756
PMCPMC12660967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.