Evidence map›Paper›PMID 41309713›Full record

Observational studyScientific reports2025

The left ventricular mechanical dispersion as a marker of disease severity in transthyretin cardiac amyloidosis.

Katarzyna Holcman, Paweł Rubiś, Bogdan Ćmiel, Andrzej Ząbek, Krzysztof Boczar, Agnieszka Stępień-Wroniecka, Katarzyna Graczyk, Krystian Mróz, Ewa Dziewięcka, Winiarczyk Mateusz and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05814380 (The Comparisons of Regional Scintigraphic DPD Uptake Between Patients With Hereditary and Wild Type Cardiac Transthyretin Amyloidosis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05814380 unknown statusnot on this map

The Comparisons of Regional Scintigraphic DPD Uptake Between Patients With Hereditary and Wild Type Cardiac Transthyretin Amyloidosis

TypeobservationalSponsorKatarzyna HolcmanRan2020 to 2024Enrolled100ConditionsTransthyretin AmyloidosisArms99mTc-DPD scintigraphy, Collection of blood samples and echocardiography
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katarzyna HolcmanDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland. katarzyna.holcman@gmail.com.ORCID https://orcid.org/0000-0002-6895-4076
Paweł RubiśDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Bogdan ĆmielFaculty of Applied Mathematics, AGH University of Krakow, Krakow, Poland.
Andrzej ZąbekDepartment of Electrocardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Krzysztof BoczarDepartment of Electrocardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Agnieszka Stępień-WronieckaDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Katarzyna GraczykDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Krystian MrózDepartment of Interventional Cardiology, Jagiellonian University Medical College, Institute of Cardiology St. John Paul II Hospital, Krakow, Poland.
Ewa DziewięckaDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Winiarczyk MateuszDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Sylwia SzczeparaDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Maria KurekStudents Scientific Group of Cardiovascular Imaging, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Krakow, Poland.
Karolina GutkowskaStudents Scientific Group of Cardiovascular Imaging, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Krakow, Poland.
Piotr PodolecDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Magdalena KostkiewiczDepartment of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.

Funding

Pfizer Research Grant ID#57165999
6 · The paper itself

Abstract

Transthyretin amyloidosis (ATTR) is a fatal disorder, thus early detection of cardiac involvement is crucial for improved clinical outcomes. This study investigated the utility of left ventricular (LV) speckle-tracking-derived mechanical dispersion as a potential marker for the assessment of cardiac amyloidosis (CA) in patients with ATTR and their first-degree relatives. This prospective, single-centre study enrolled 100 adults from 2020 to 2024 (ClinicalTrials NCT05814380). Participants underwent clinical assessment, genetic testing, and [

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesHeart VentriclesVentricular Dysfunction, LeftVentricular Function, LeftAgedBiomarkersEchocardiographyFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainProspective StudiesSeverity of Illness IndexStroke VolumeBiomarkersNatriuretic Peptide, BrainAmyloidosisATTRMechanical dispersionSpeckle-tracking echocardiography

Identifiers

PMID41309713
PMCPMC12660686

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.