ArticleNature communications2025
Human plasma proteomic profile of clonal hematopoiesis.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed.
- Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy.Cells · 2026Review
- Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms.Journal of clinical medicine · 2026Review
- Clonal Hematopoiesis of Indeterminate Potential and Cardiometabolic Disease: Challenges, Controversies and Future Perspectives.International journal of molecular sciences · 2025Review
- Interleukin-17 receptor-A signalling: atheroprotective role in JAK2 clonal haematopoiesis.European heart journal · 2025Article
- Differences in the mutational landscape of clonal hematopoiesis of indeterminate potential among races and between male and female patients with cancer.Experimental hematology · 2024Article
- The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations.medRxiv : the preprint server for health sciences · 2024Article
- Digital health technology empowering China's community full life cycle health management.Digital healthReview
Corrections and comments
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Authors and funding
53 authors.
Zhi YuClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-4810-3474
Amélie VrommanDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.ORCID 0000-0002-1724-2095
Ngoc Quynh H NguyenDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Art SchuermansBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8146-9692
Linke LiClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0002-6350-5121
Thiago RentzDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Tetsushi NakaoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9979-2682
Shamsudheen K VellarikkalDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.
Md Mesbah UddinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1846-0411
Abhishek NiroulaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5904-0635
Gabriel GriffinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4042-6757
Michael C HonigbergBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8630-5021
Amy E LinDivision of Cardiology, Section of Cardio-Oncology and Immunology, University of California-San Francisco, San Francisco, CA, USA.
Christopher J GibsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3700-5310
Daniel H KatzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-7237-8502
Usman A TahirDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-3657-6082
Shi FangDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jacqueline S DronBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3045-6530
Michael PanCardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0009-8529-897X
Sara HaidermotaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Shriienidhie GaneshBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4226-7526
Tajmara AntoineBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Joshua WeinstockDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7013-1899
Thomas R AustinCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Ramachandran S VasanUniversity of Texas Health Sciences Center, San Antonio, TX, USA.ORCID 0000-0001-7357-5970
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-5355-8636
Whitney HornsbyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Peter GanzDivision of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0002-0437-8882
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-9426-7595
Bernhard HaringDepartment of Medicine IV, Clinic Hietzing, Vienna, Austria.ORCID 0000-0001-6109-431X
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-1427-4470
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3409-1110
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Yuan-I MinDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0003-2470-0004
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-9501-600X
Leslie A LangeDepartment of Medicine, Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8655-5204
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-7191-1723
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Benjamin L EbertBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0197-5451
Bing YuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-4818-1077
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6432-1730
Josef CoreshDepartments of Population Health and Medicine, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-4598-0669
Vijay G SankaranBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0044-443X
Alexander G BickDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5824-9595
Siddhartha JaiswalDepartment of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9597-0477
Robert E GersztenDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6767-7687
NHLBI Trans-Omics for Precision Medicine
Peter LibbyDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.ORCID 0000-0002-1502-502X
Rajat M GuptaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9865-4106
Pradeep NatarajanBroad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.ORCID 0000-0001-8402-7435
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MAfrican Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MPolygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MAmerican Heart Association (American Heart Association, Inc.) 24RGRSG1275749, 25SFRNCCKMS1443062, 25SFRNPCKMS1463898American Heart Association-American Stroke Association 24RGRSG1275749American Heart Association-American Stroke Association 25SFRNCCKMS1443062American Heart Association-American Stroke Association 25SFRNPCKMS1463898Burroughs Wellcome Fund (BWF) Burroughs Wellcome Foundation Career Award for Medical ScientistsFondation Leducq TNE-18CVD04Harvard Medical School Harold M. English Fellowship FundMassachusetts General Hospital (MGH) Paul and Phyllis Fireman Endowed Chair in Vascular MedicineNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS R00 HG012956NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS DP2 HL157540NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL161445NHLBI NIH HHS K99 HL165024NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL134320NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL151283NHLBI NIH HHS R01 HL153499NHLBI NIH HHS R01 HL159081NHLBI NIH HHS R01 HL163099NHLBI NIH HHS R01 HL172803NHLBI NIH HHS R01 HL173028NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK125782NIDDK NIH HHS U01 DK108809NIH HHS 75N98025D00022NIH HHS 75N98025D00024NIH HHS 75N98025D00025NIH HHS 75N98025D00026NIH HHS 75N98025D00027NIH HHS 75N98025D00028NIH HHS DP5 OD029586NIMHD NIH HHS HHSN268201800013INIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH123451Science for Life Laboratory (SciLifeLab) KAW 2020.0239U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL134892 and 1R01HL163099-01U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01 HL159081, R01 HL153499U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K08HL161445U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K99HL165024U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142711, R01HL127564, R01HL148050, R01HL151283, R01HL148565, R01HL135242, and R01HL151152U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148565U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL173028, R01HL148565U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R00HG012956U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 5U01DK108809U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK125782U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01 MH104964 and R01 MH123451
Abstract
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations show substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic Tet2-/- vs wild-type mice validation, disentangle causal proteomic perturbations from TET2 CHIP. Lastly, we identify plasma proteins shared between CHIP and CAD.
Indexed as
Blood ProteinsClonal HematopoiesisProteomeProteomicsAgedAnimalsCoronary Artery DiseaseDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHumansMaleMendelian Randomization AnalysisMiceASXL1 protein, humanBlood ProteinsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseProteomeProto-Oncogene ProteinsRepressor ProteinsTET2 protein, human
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