Evidence map›Paper›PMID 41309672›Full record

ArticleScientific reports2025

The anti-aging potential of VA'S new derivatives through metabolomic profiling.

Li Tan, Jiang Wu, Jiewen Wang, Hongkang Zhang, Wei Zhang, Ang Gao, Zhijian Zhong, Tie-Gen Chen, Baoping Zhou, Tengfei Han and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Li Tan *The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China.
Jiang Wu *Shanghai Coachchem Technology, Shanghai, China. johnnywu@coachchem.com.
Jiewen WangThe Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China.
Hongkang ZhangThe Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China.
Wei ZhangShanghai Coachchem Technology, Shanghai, China.
Ang GaoShanghai Coachchem Technology, Shanghai, China.
Zhijian ZhongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tie-Gen ChenShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Baoping ZhouShanghai Coachchem Technology, Shanghai, China.
Tengfei HanShanghai Coachchem Technology, Shanghai, China.
Die ZhangShanghai Coachchem Technology, Shanghai, China.
Miao HeInstitute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China.
Zhenxin FanThe Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China. zxfan@scu.edu.cn.
Ya ZhouInstitute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China. zhouya@ibt.pumc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin aging is a complex process influenced by intrinsic and extrinsic factors, leading to structural and functional changes such as reduced elasticity and increased wrinkles. This study aims to evaluate the potential biological functions of Magic vitamin A (MVA) in skin health management and skin aging through metabolomics analysis. We performed untargeted metabolomics analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to explore the changes in metabolites and related metabolic pathways induced by MVA in HaCaT cells. This suggests that MVA treatment substantially alters the cellular metabolic state. The boxplot analysis indicates that MVA altered the levels of several metabolites, including 18-beta-Glycyrrhetinic acid, Palmitoylethanolamide (PEA), 17-AAG, L-arginine, and Dehydroepiandrosterone (DHEA), all of which exhibit significant biological effects in anti-aging, anti-inflammatory, and antioxidant properties. Additionally, key metabolic pathways, such as Arginine and proline metabolism, Purine metabolism, and Arachidonic acid metabolism, also highlighted potential anti-aging pathways of MVA. Our findings suggest that MVA may improve skin health through multiple metabolic mechanisms, supporting its potential as an anti-aging agent.

Indexed as

MetabolomeMetabolomicsSkin AgingVitamin AAmidesAntioxidantsArginineChromatography, LiquidEthanolaminesHaCaT CellsHumansMetabolic Networks and PathwaysPalmitic AcidsTandem Mass SpectrometryAmidesAntioxidantsArginineEthanolaminespalmidrolPalmitic AcidsVitamin AAnti-agingMetabolomicsMolecular synthesisMVA

Identifiers

PMID41309672
PMCPMC12663416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.