Evidence map›Paper›PMID 41309663›Full record

Articlenpj aging2025

Space radiation induces distinct senescent phenotypes: Implications for space travel.

Louise E Pitcher, Bipasha Mukherjee, Ashley M Saathoff, Zachary A Eduvas, Josh Bartz, Xu Zhang, Nino Giorgadze, Tamar Pirtskhalava, Amyn A Habib, Nathan K LeBrasseur and 5 more

Abstract read
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Louise E PitcherMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Bipasha MukherjeeDepartment of Neurosurgery, University of Texas Health Science Center, San Antonio, TX, USA.
Ashley M SaathoffMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Zachary A EduvasMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Josh BartzMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota and Department of Genetics, Cell Biology, and Development, 420 Washington Avenue SE, Minneapolis, MN, USA.
Xu ZhangRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Nino GiorgadzeCenter for Advanced Gerotherapeutics, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Tamar PirtskhalavaCenter for Advanced Gerotherapeutics, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Amyn A HabibDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Tamara TchkoniaCenter for Advanced Gerotherapeutics, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
James L KirklandCenter for Advanced Gerotherapeutics, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xiao DongMasonic Institute on the Biology of Aging and Metabolism, University of Minnesota and Department of Genetics, Cell Biology, and Development, 420 Washington Avenue SE, Minneapolis, MN, USA.
Sandeep BurmaDepartment of Neurosurgery, University of Texas Health Science Center, San Antonio, TX, USA. burma@uthscsa.edu.
Paul D RobbinsMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu.

Funding

Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
PROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2M
Minnesota Tissue Mapping Center for Senescent CellsU54AG076041 · NIA · UNIVERSITY OF MINNESOTA · PI Constantin F. Aliferis, LAURA Jane NIEDERNHOFER · 2021 to 2026
$10.5M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Translational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2M
Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain TumorsR01CA258381 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BURMA, SANDEEP · 2021 to 2025
$2.8M
Inflammation, Lipid Metabolism and SenescenceR01AG069819 · NIA · UNIVERSITY OF MINNESOTA · PI CAMELL, CHRISTINA · 2020 to 2024
$1.9M
Radiation-induced senescence in the brain microenvironment: Implications for glioblastoma recurrence and therapyR01CA246807 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BURMA, SANDEEP · 2021 to 2025
$1.8M
Molecular mechanisms of GBM radioresistance and strategies for radiosensitizationR01CA149461 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI BURMA, SANDEEP · 2011 to 2015
$1.6M
NASA 80NSSC20K0732NCI NIH HHS R01 CA149461NCI NIH HHS R01 CA246807NCI NIH HHS R01 CA258381NIA NIH HHS P01 AG043376NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG069819NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS T32 AG029796NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079754NIH HHS P01 AG062413NIH HHS R01 CA246807NIH HHS T32AG029796
6 · The paper itself

Abstract

As Earth's magnetic field weakens, space radiation begins to pose a significant threat to the health of not only space travelers, but the world's population. Space radiation, comprising high-energy and high-charge ions, creates distinct clusters of DNA damage and dense macromolecular damage that result in the accumulation of senescent cells (SnCs) known to play a critical role in promoting multimorbidity. Here, we demonstrate that human fibroblasts exposed to different forms of space radiation acquire senescence-associated phenotypes including morphological alterations and the accumulation of SA-ß-gal

Identifiers

PMID41309663
PMCPMC12660773

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.