ArticleNature communications2025
Robust biodegradable synapse with sub-biological energy and extended memory for intelligent reflexive system.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Anti-Freezing Fiber-Shaped Iontronic Synapses With Ultralow Energy Consumption and High Rectification.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Robust biodegradable synapse with sub-biological energy and extended memory for intelligent reflexive system.Nature communications · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Biodegradable artificial synapses hold great promise for sustainable neuromorphic electronics, yet combining long-term memory, ultralow energy consumption, and mechanical robustness remains challenging. Here, we report a fully biodegradable multilayer artificial synapse (M-AS) composed of crosslinked chitosan-guar gum (CS-GG) ion-active layers (IALs) and a cellulose acetate (CA) ion-binding layer (IBL). This trilayer architecture enhances ion trapping via ion-dipole coupling (IDC) at the IAL-IBL interface, while hydrogen-bonded crosslinking within the CS-GG matrix enhances mechanical and environmental stability. Sodium chloride, embedded in the IALs, serves as a mobile ionic species analogous to biological neurotransmitters, enabling low-voltage ion migration. Upon electrical stimulation, ion migration and dipole alignment induce IDC, leading to partial ion retention and cascade-like postsynaptic current responses that support memory formation. The M-AS supports key synaptic functionalities-including paired-pulse facilitation, short-term and long-term plasticity, multilevel memory encoding, and bidirectional modulation-under sub-millivolt operation. It achieves the longest long-term memory time (5944 s) reported among biodegradable artificial synapses and an energy consumption (0.85 fJ/event) lower than that of biological synapses. Integration with a thermistor and robotic actuator enables a bioinspired reflexive system capable of adaptive, stimulus-dependent learning and reflex-like behaviors. These results demonstrate the potential of M-AS for low-power, intelligent human-machine interfaces.
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Registered trials
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