Evidence map›Paper›PMID 41309509›Full record

ArticleClinical endoscopy2025

Effect of double-layered suturing for mucosal defect closure after colorectal endoscopic submucosal dissection on postoperative adverse events: a propensity score-matched retrospective study in Japan.

Kyohei Nishino, Hiroki Fujita, Takahiro Yuge, Masanori Hongo, Naoko Mori, Kazumi Shimamoto, Yu Kobayashi, Takashi Toyonaga, Hiromitsu Ban

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kyohei NishinoDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Hiroki FujitaDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Takahiro YugeDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Masanori HongoDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Naoko MoriDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Kazumi ShimamotoDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Yu KobayashiDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.
Takashi ToyonagaDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Hyogo, Japan.
Hiromitsu BanDepartment of Gastroenterology, Omi Medical Center, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProphylactic closure of mucosal defects after colorectal endoscopic submucosal dissection (ESD) can reduce the incidence of postoperative adverse events. However, data on this notion are limited. This study retrospectively evaluated the effect of closure using a double-layered suturing technique on postoperative adverse events.

methodsA total of 370 lesions in 317 patients who underwent colorectal ESD were included in this analysis. Patients with 197 lesions that were completely closed were then assigned to the closure group. Patients with 173 lesions, including 55 that were partially closed and 118 that were not closed, were assigned to the non-closure group. Propensity score matching was performed, and 136 lesions were selected for each group.

resultsThe closure group had a significantly lower overall incidence rate of postoperative adverse events, including delayed bleeding, delayed perforation, and post-ESD electrocoagulation syndrome, than the non-closure group (2.2% vs. 9.6%, p=0.018). The closure group had a significantly lower incidence of abdominal pain on the day after ESD than the non-closure group (2.9% vs. 11.0%, p=0.015).

conclusionsProphylactic closure of mucosal defects after colorectal ESD using a double-layered suturing technique could prevent postoperative adverse events and abdominal pain on the day after ESD.

Indexed as

Abdominal painColorectal neoplasmsEndoscopic submucosal dissectionPostoperative complicationsWound closure techniques

Identifiers

PMID41309509
PMCPMC12933538

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