Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair.

Xinyu Thomas Tang, Yiming Liam Liu, Yidi Augenstern Du, Shan Shan Wang, Bo O Zhou

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyu Thomas TangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Yiming Liam LiuKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Yidi Augenstern DuKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Shan Shan WangDepartment of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, China.

Bo O ZhouKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.ORCID https://orcid.org/0000-0001-8950-8799

Funding

China Postdoctoral Science Foundation under Grant Number 2024M763252National Key Program on Stem Cell and Translational Research 2022YFA1104100National Natural Science Foundation of China 32270785National Natural Science Foundation of China 32425020National Natural Science Foundation of China 32500631National Natural Science Foundation of China 82273292National Natural Science Foundation of China 92368101Shanghai Municipal Science and Technology Major Project Fund, Shanghai Science and Technology Commission 22XD1424000Shanghai Municipal Science and Technology Major Project Fund, Shanghai Science and Technology Commission 22ZR1469000Strategic Priority Research Program of Chinese Academy of Science XDB0980000

6 · The paper itself

Abstract

Culture-expanded mesenchymal stromal cells (MSCs) are capable of fostering tissue regeneration after transplantation. However, the behavior and physiological role of endogenous MSCs in distal organ repair remain undetermined. In this study, a suite of genetic tools is generated to distinguish MSCs between tissues, and to map their fate in local, proximate, and distal organ repair. By single-cell RNA-sequencing, it is found that the transcriptomic profiles of most non-bone marrow-derived mesenchymal stromal cells (nonBM-MSCs) exhibited high similarities, yet differed from that of bone marrow-derived mesenchymal stromal cells (BM-MSCs), especially in their less abundant secretome. Fate-mapping experiments demonstrated that BM-MSCs do not contribute to the formation of myofibroblasts during fibrosis or cancer-associated fibroblasts (CAFs) during tumorigenesis. In contrast, MSCs from proximate tissues actively migrated to the site of bone fracture, where they contributed to the formation of fibrocartilaginous soft callus. During injury-associated inflammation, local MSCs modulated the polarization of tissue-resident macrophages, whereas BM-MSCs mobilized monocytes to the site of inflammation. Conditional deletion of Ccl2 in BM-MSCs, but not in colon-resident MSCs, ameliorated colon inflammation and restored body weight after colitis. Thus, injury repair is orchestrated by MSCs from multiple sources, with local, proximate, and distal MSCs acting through different mechanisms.

Indexed as

Mesenchymal Stem CellsWound HealingAnimalsHumansMiceMice, Inbred C57BLcancer associated fibroblastfibrosisinflammationmesenchymal stromal cellsmyofibroblast

Identifiers

PMID41309504

DOI10.1002/advs.202509533

PMCPMC12806335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.