ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Advancing the Tendinopathy Triad: Comment on "Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity".
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Rational design of immunological programs for functional regenerative niches.Materials today. Bio · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.-which elegantly connects mechanical stress, inflammation, and vascularity-this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad.</mark> A paradigm shift is proposed toward spatiotemporal multi-omics deconstruction of tendon pathology, emphasizing the role of epigenetically driven cellular re-programming in tendon stem/progenitor cells and the emergence of neuro-immune-vascular niches as functional units sustaining chronicity. Furthermore, redox-mechanobiological integration through sensors such as TNIK and the potential of 4D-bioprinted smart biomaterials for chrono-specific therapeutic delivery are explored. By incorporating advanced computational approaches, including AI-powered digital tendon twins, a transformative roadmap is outlined for translating the homeostatic failure model into precisely targeted, mechanism-based diagnostics and therapies. This perspective aims to stimulate interdisciplinary innovation and position tendinopathy research at the forefront of musculoskeletal science.
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Registered trials
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