Evidence map›Paper›PMID 41309380›Full record

ArticleAnalytical chemistry2025

Phenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer.

Emmanouil Mavrakis, G Thomas Knecht, Maxwell J Unger, Alison R H Narayan, Robert T Kennedy

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Machine vision-enabled ODThe Analyst · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emmanouil MavrakisDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48103, United States.ORCID 0000-0001-7502-5577
G Thomas KnechtDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48103, United States.ORCID 0009-0003-3800-3434
Maxwell J UngerDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48103, United States.ORCID 0000-0002-6081-8344
Alison R H NarayanDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48103, United States.ORCID 0000-0001-8290-0077
Robert T KennedyDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48103, United States.ORCID 0000-0003-2447-7471

Funding

Microfluidic Systems to Enable Enzyme Engineering for Chemical SynthesisR01GM150948 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERT T KENNEDY · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM150948
6 · The paper itself

Abstract

Biotechnology is increasingly relying on high-throughput experiments in which large populations of cells are phenotyped and selected based on performance, e.g., for producing a desired product. Droplet microfluidics enables high-throughput screening, and as such, it lends itself ideally to such experiments, but reliance on a fluorescent readout is limiting. Herein, we report a system integrating droplet electrospray ionization-mass spectrometry (ESI-MS) with a microfluidic voltage-mediated droplet printer to enable online analysis and capture of cell-containing aqueous droplets, ultimately offering the possibility for label-free phenotyping and selection of cells.

Indexed as

Escherichia coliLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesSpectrometry, Mass, Electrospray IonizationPhenotype

Identifiers

PMID41309380
PMCPMC12961634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.