Evidence map›Paper›PMID 41309271›Full record

ArticleThe European respiratory journal2026

Lower lobe mucus plug distribution and future respiratory exacerbations in tobacco-exposed individuals with and without COPD.

Emily S Wan, Ruchita Borgaonkar, Sofia Mettler, Pietro Nardelli, Monica Iturrioz-Campo, Padma P Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Scott Grumley and 6 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emily S WanVA Boston Healthcare System, Jamaica Plain, MA, USA emily.wan@va.gov.ORCID https://orcid.org/0000-0002-4126-2467
Ruchita BorgaonkarBrigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0009-0003-2947-2757
Sofia MettlerBrigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7553-1346
Pietro NardelliBrigham and Women's Hospital, Boston, MA, USA.
Monica Iturrioz-CampoBrigham and Women's Hospital, Boston, MA, USA.
Padma P ManapragadaUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Mostafa AbozeedUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Muhammad Usman AzizUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Mohd ZahidUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Scott GrumleyUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Andrew YenUniversity of California San Diego, San Diego, CA, USA.
Sushilkumar SonavaneMayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-8823-7261
Wei WangBrigham and Women's Hospital, Boston, MA, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4907-1657
Raul San José EstéparBrigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-3677-1996
Alejandro A DiazBrigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5037-2919

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2M
Understanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7M
Clinical implications and Proteomics of Bronchiectasis Progression in SmokersR01HL173017 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Alejandro Diaz, Raul San Jose Estepar · 2024 to 2026
$2.6M
CSRD VA I01 CX002193NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL164824NHLBI NIH HHS R01 HL173017NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41309271
PMCPMC12859690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.