Evidence map›Paper›PMID 41309269›Full record

Observational studyThe European respiratory journal2026

Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk.

Jeeyon G Rim, Jeremy M Weber, Megan L Neely, Nicholas O'Grady, Francine L Kelly, Rachel A Myers, Andrew Nagler, Patrick McArthur, Courtney W Frankel, John A Belperio and 10 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jeeyon G RimDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA jeeyongracerim@gmail.com.ORCID https://orcid.org/0009-0002-0416-2480
Jeremy M WeberDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Megan L NeelyDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Nicholas O'GradyDepartment of Medicine, Clinical Research Unit, Duke University School of Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0001-8711-7508
Francine L KellyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Rachel A MyersDepartment of Medicine, Clinical Research Unit, Duke University School of Medicine, Durham, NC, USA.
Andrew NaglerDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Patrick McArthurDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Courtney W FrankelDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
John A BelperioDivision of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, University of California Los Angeles, Los Angeles, CA, USA.
Marie BudevDepartment ofPulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.
Matthew G HartwigDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Tereza MartinuUniversity Health Network, University of Toronto, Toronto, ON, Canada.
John M ReynoldsDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Pali D ShahDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Lianne G SingerUniversity Health Network, University of Toronto, Toronto, ON, Canada.
Laurie D SnyderDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
S Samuel WeigtDivision of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, University of California Los Angeles, Los Angeles, CA, USA.
Scott M PalmerDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Jamie L ToddDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID https://orcid.org/0000-0003-4247-3693

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung transplant recipients with lower club cell secretory protein (CCSP) levels in bronchoalveolar lavage fluid (BALF) early post-transplantation are at increased risk for chronic lung allograft dysfunction (CLAD). For CLAD risk stratification, we previously identified a potential risk threshold for reduced CCSP (protein-normalised CCSP <8.63 ng·µg

methodsTotal protein and CCSP were quantified in 1481 BALF samples collected over the first post-transplant year from 353 patients (validation cohort). A Cox model tested the association between time to first CCSP <8.63 ng·µg

resultsBALF CCSP <8.63 ng·µg

conclusionsEarly post-transplant reductions in BALF CCSP identify lung recipients at increased CLAD risk and may associate with heightened allograft inflammation.

Indexed as

Bronchoalveolar Lavage FluidGraft RejectionLungLung TransplantationPrimary Graft DysfunctionUteroglobinAdultAgedAllograftsFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk AssessmentSCGB1A1 protein, humanUteroglobin

Identifiers

PMID41309269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.