Evidence map›Paper›PMID 41309230›Full record

ArticleJournal of microbiology (Seoul, Korea)2025

Inhibition of cardiolipin biosynthesis partially suppresses the sensitivity of an Escherichia coli mutant lacking OmpC to envelope stress.

Dae-Beom Ryu, Umji Choi, Gyubin Han, Chang-Ro Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dae-Beom RyuDepartment of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Umji ChoiDepartment of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Gyubin HanDepartment of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.
Chang-Ro LeeDepartment of Biological Sciences, Myongji University, Yongin 17058, Republic of Korea.

Funding

Ministry of EducationNational Research Foundation of Korea NRF-RS-2023-00246684
6 · The paper itself

Abstract

Porins in the outer membrane (OM) of Gram-negative bacteria play two main functions: passage of various extracellular molecules and maintenance of membrane integrity. OmpC, a non-specific porin, is involved in both functions; however, the exact mechanism of maintenance of membrane integrity remains unknown. In this study, we found that inhibiting cardiolipin biosynthesis partially restored the growth defect of the ompC mutant under envelope stress. Among the three enzymes involved in cardiolipin biosynthesis, ClsABC, this effect is primarily associated with ClsA. Notably, the deletion of ClsA also suppressed the similar phenotypes of an Escherichia coli mutant lacking YhdP, a transmembrane protein involved in phospholipid transport from the inner membrane to the OM. Collectively, these results imply that OmpC may contribute to membrane integrity, partially through mechanisms linked to transport or biosynthesis of phospholipids such as cardiolipin.

Indexed as

CardiolipinsEscherichia coliPorinsBacterial Outer MembraneBacterial Outer Membrane ProteinsCell MembraneEscherichia coli ProteinsMutationStress, PhysiologicalBacterial Outer Membrane ProteinsCardiolipinsEscherichia coli ProteinsOmpC proteinPorinscardiolipinmembrane integrityOmpCphospholipid transportporinsYhdP

Identifiers

PMID41309230
PMCPMC13577075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.