Evidence map›Paper›PMID 41309144›Full record

ArticleBMJ global health2025

Availability of essential medicines for non-communicable diseases: a scoping review of challenges and opportunities.

Iris R Joosse, Aukje Mantel-Teeuwisse, Hendrika A van den Ham, Lourdes Cantarero Arevalo

Abstract readScoping Review
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Bioactive Fractions fromMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iris R JoosseUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-7677-8589
Aukje Mantel-TeeuwisseUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands A.K.Mantel@uu.nl.ORCID 0000-0002-8782-0698
Hendrika A van den HamUtrecht WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-1339-9818
Lourdes Cantarero ArevaloWHO Collaborating Center for Research and Training in the Patient Perspective on Medicines Use, Department of Pharmacy, Faculty of health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGiven the critical role of medicines in reducing the burden of non-communicable diseases (NCDs), we analysed factors that hinder the availability of quality medicines for managing NCDs at the point of service delivery, with a particular focus on low-income and middle-income countries.

methodsIn this scoping review, literature published in PubMed, Embase, Web of Science, the World Bank eLibrary and the WHO's Institutional Repository for Information Sharing (WHO IRIS) was collected (January 2009-May 2025). Literature was excluded if it did not specifically address NCD medicines, discussed global rather than national determinants of availability only, failed to detail supply chain inefficiencies or exclusively reported on other dimensions of access (ie, pricing/affordability, trial access, regulatory access). From cross-sectional assessments of medicine availability, mean availability was extracted, and from quantitative, interventional studies, details on the intervention and its effectiveness on NCD medicine availability were extracted. From the remaining studies, descriptions of barriers and recommendations or empirically proven interventions to improve availability were extracted and mapped according to the pharmaceutical value chain (PVC).

resultsOur review of 3348 records identified 83 eligible studies. The mean availability of NCD medicines reported in cross-sectional surveys was suboptimal (<80%) in 39 of 46 surveyed countries. We found barriers to available NCD medicines across all components of the PVC. Deficiencies in governance, financing, the health workforce, health information systems and service delivery underscore the interlinkage of various health system building blocks and stakeholders in determining availability. Nonetheless, most barriers pertained to supply chain inefficiencies, followed by challenges in regulatory systems and quality monitoring.

conclusionsThe evidence highlights the need for political commitment to NCDs, broad stakeholder involvement, integrated stock management systems and increased human resources to make NCD medicines more available to patients worldwide.

Indexed as

Drugs, EssentialHealth Services AccessibilityNoncommunicable DiseasesDeveloping CountriesGlobal HealthHumansDrugs, EssentialCancerCardiovascular diseaseDiabetesHealth Services AccessibilityPharmacology

Identifiers

PMID41309144
PMCPMC12666150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.