Evidence map›Paper›PMID 41309049›Full record

ArticleJournal of biomedical research2025

A new strategy to reduce human influenza infection: creating pigs with partial resistance to influenza A virus infection by targeting

Lin Li, Shuyi Fang, Xiaoxue Li, Jingjing Liu, Wenhan Lu, Qinyuan Li, Jianghao Chang, Yilin Yuan, Bin Fang, Ying Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lin LiDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Shuyi FangDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xiaoxue LiDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jingjing LiuDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Wenhan LuDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qinyuan LiDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jianghao ChangDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yilin YuanGcreatene (Suzhou) Biotechnology Co., Ltd, Suzhou Industrial Park, Suzhou, Jiangsu 215000, China.
Bin FangGcreatene (Suzhou) Biotechnology Co., Ltd, Suzhou Industrial Park, Suzhou, Jiangsu 215000, China.
Ying WangDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yi RaoPeking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Haiyuan YangDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yifan DaiDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major threat to the global human population is zoonosis, which refers to viral infections transmitted from animals. Pigs are crucial to the transmission of the influenza A virus (IAV) because they express both human-type (α-2,6-linked) and avian-type (α-2,3-linked) sialic acid (SA) receptors, making them a direct source of zoonosis and providing essential "mixing vessels" for avian and swine viruses. We aimed to mitigate the IAV threat by disrupting pig influenza infection through gene targeting of the viral receptors in pigs. We utilized CRISPR/Cas9 to knock out the

Indexed as

gene-edited pigsinfluenza A virusST3GAL4ST6GAL1

Identifiers

PMID41309049
PMCPMC13620455

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.