Observational studyThe Journal of international medical research2025
Pharmacokinetics of imipenem in critically ill patients: Continuous infusion versus extended infusion in a real-world study.
Observational study in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative efficacy and safety of extended versus continuous infusion of beta-lactam antibiotics for severe infection: a network meta-analysis of randomized trials.Critical care (London, England) · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
ObjectiveThis study compared the pharmacokinetic/pharmacodynamic properties of extended infusion and continuous infusion of imipenem at equivalent daily doses in a real-world setting.MethodsIn this prospective observational study, physicians adjusted imipenem doses empirically based on renal function and infection severity. Plasma concentrations were quantified via liquid chromatography-mass spectrometry, and pharmacokinetic parameters were calculated. Pharmacokinetic/pharmacodynamic targets were defined as 100% of the dosing interval with free drug concentrations above the minimum inhibitory concentration (MIC) and four times above the MIC, with MICs set at 1, 2, 4, 8, and 16 mg/L.ResultsThe analysis included 20 patients with extended infusion (0.5 g q6h/q8h or 1 g q8h) and 20 with continuous infusion (matched doses). Continuous infusion showed lower trough concentration variability (coefficient of variation: 25.5% vs. 67.3%) and significantly higher area under the curve and minimum plasma concentration values at all doses (
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