Evidence map›Paper›PMID 41309009›Full record

ArticleAnnals of epidemiology2026

Impact of integrase strand transfer inhibitors on cardiovascular disease in people with HIV.

Buwei He, Bankole Olatosi, Jiajia Zhang, Sharon Weissman, Xiaoming Li, Xueying Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Buwei HeDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; South Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA. Electronic address: buwei@email.sc.edu.
Bankole OlatosiSouth Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Jiajia ZhangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; South Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Sharon WeissmanSouth Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; Department of Internal Medicine, School of Medicine, University of South Carolina, Columbia, SC 29208, USA.
Xiaoming LiSouth Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Xueying YangSouth Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.

Funding

Patterns and predictors of viral suppression: A Big Data approachR01AI164947 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI OLATOSI, BANKOLE, ZHANG, JIAJIA · 2021 to 2025
$4.4M
National Institute of Allergy and Infectious Diseases R01AI164947NIAID NIH HHS R01 AI164947
6 · The paper itself

Abstract

purposeIntegrase Strand Transfer Inhibitors (INSTIs) are effective and well-tolerated in HIV treatment, but their cardiovascular impact remains uncertain. This study evaluated the association between INSTI-based antiretroviral therapy (ART) and cardiovascular disease (CVD) risk in people with HIV (PWH).

methodsWe conducted a retrospective cohort study using electronic health records and survey data from the All of Us research program. Adults with HIV on continuous ART for ≥ 1 year, free of CVD at baseline and within one year of ART initiation, were included. INSTI exposure was categorized by regimen status. Cox proportional hazards models assessed the association between INSTI use and CVD. A subgroup analysis examined INSTI-naïve individuals who later switched to INSTI-based ART.

resultsAmong 2175 PWH, 437 (20.09 %) experienced CVD events; 1715 (78.85 %) used INSTIs. INSTI-only (aHR = 0.65, 95 % CI: 0.50-0.83) and partial-INSTI use (aHR = 0.34, 95 % CI: 0.27-0.42) were linked to lower CVD risk. In the INSTI-naïve cohort (N = 1300), switching to INSTIs reduced CVD risk (aHR = 0.32, 95 % CI: 0.25-0.40). Older age (≥ 70) increased CVD risk.

conclusionsINSTI-based ART may lower CVD risk among PWH. Further research is needed to validate these findings. SUMMARY: INSTI-based ART was associated with reduced cardiovascular disease risk among people with HIV, suggesting potential cardioprotective effects that warrant further investigation.

Indexed as

Cardiovascular DiseasesHIV InfectionsHIV Integrase InhibitorsAdultFemaleHumansMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesRisk FactorsUnited StatesHIV Integrase InhibitorsAntiretroviral therapyCardiovascular diseaseINSTIPeople with HIV

Identifiers

PMID41309009
PMCPMC13318472

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.