Evidence map›Paper›PMID 41308755›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration.

Caroline Anselmi, Renan Dal-Fabbro, Hisham Abada, Igor Paulino Mendes Soares, Lais M Cardoso, Abdel H Mahmoud, Julia C Catalano, Ana Beatriz Gomes de Carvalho, Yuanyuan Han, Prabaha Sikder and 3 more

Abstract read
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In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. [Frontier research on smart delivery biomaterials in the field of oral tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caroline AnselmiDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University, Araraquara, Brazil.
Renan Dal-FabbroDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Hisham AbadaDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Endodontics, Faculty of Dentistry, Kafrelsheikh University, Kafrelsheikh, Egypt.
Igor Paulino Mendes SoaresDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University, Araraquara, Brazil.
Lais M CardosoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University, Araraquara, Brazil.
Abdel H MahmoudDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Julia C CatalanoDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Ana Beatriz Gomes de CarvalhoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Yuanyuan HanDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Prabaha SikderDepartment of Mechanical Engineering, Cleveland State University, Cleveland, OH, USA.
Anna SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
Josimeri HeblingDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University, Araraquara, Brazil.
Marco C BottinoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: mbottino@umich.edu.

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
NIDCR NIH HHS R01 DE031476
6 · The paper itself

Abstract

Balancing pulp tissue inflammation and dentin regeneration is essential for maintaining tooth responsiveness and reparative ability in vital pulp therapy (VPT). Here, we describe a photocrosslinkable gelatin methacryloyl (GelMA) biomaterial electrospun into a bilayer fibrous scaffold with clinically relevant functions. It comprises a 10 % (w/v) GelMA layer loaded with ibuprofen (IBP, 10 % or 20 % w/w) for immunomodulation, and a 20 % GelMA layer containing amorphous magnesium phosphate (AMP, 5 % or 15 % w/w) to promote biomineralization. Fiber morphology, chemical composition, mechanical properties, swelling, enzymatic degradation, and release kinetics of IBP and Mg

Indexed as

Anti-Inflammatory Agents, Non-SteroidalDental PulpDentinGelatinIbuprofenMethacrylatesTissue ScaffoldsAnimalsBiocompatible MaterialsCells, CulturedHumansInflammationMacrophagesMaleRegenerationStem CellsAnti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsGelatingelatin methacryloylIbuprofenMethacrylatesDental pulpDentistryGelatin methacryloylMineralized tissuePolymer nanofibersPulp cappingRegeneration

Identifiers

PMID41308755
PMCPMC13011891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.