Evidence map›Paper›PMID 41308729›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2026

Psychosocial stressors as modifiers of the associations between well-studied and understudied chemicals and birth outcomes in the ECHO Cohort.

Stephanie M Eick, Patricia A Brennan, Jessie P Buckley, Donghai Liang, Xiuhong Li, Kayla L Karvonen, Whitney Cowell, Yeyi Zhu, Emily S Barrett, Alicia K Peterson and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address: stephanie.marie.eick@emory.edu.
Patricia A BrennanDepartment of Psychology, Emory University School of Medicine, Atlanta, GA, United States.
Jessie P BuckleyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Xiuhong LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Kayla L KarvonenDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, United States.
Whitney CowellDepartment of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States; Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States.
Yeyi ZhuKaiser Permanente Northern California, Division of Research, Pleasanton, CA, United States.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, United States.
Alicia K PetersonKaiser Permanente Northern California, Division of Research, Pleasanton, CA, United States.
Brennan H BakerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States; Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, United States.
Max AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Rachel Morello-FroschSchool of Public Health and Department of Environmental Science, Policy and Management, University of California, Berkeley, Berkeley, CA, United States. Electronic address: rmf@berkeley.edu.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
MyDzung T ChuInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.
Julia VarshavskyDepartment of Public Health and Health Sciences and Civil and Environmental Engineering, Northeastern University, Boston, MA, United States; Department of Civil and Environmental Engineering, Northeastern University, Boston, MA, United States.
Christine W HockettAvera Research Institute, Sioux Falls, SD, United States; Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, SD, United States.
Courtney C CarignanDepartment of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.
Jiwon OhDepartment of Public Health Sciences, University of California Davis, Davis, CA, United States.
Anne L DunlopDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, United States.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and ProcessingU24OD035523 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Suman Ranjan Das, NATASHA Bassam HALASA · 2023 to 2026
$32.8M
Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
NCATS NIH HHS UL1 TR004419NIEHS NIH HHS K01 ES035082NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES023513NIEHS NIH HHS U24 ES026539NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026542NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030851NIEHS NIH HHS U2C ES030857NIEHS NIH HHS U2C ES030859NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U24 OD035523NIH HHS U2C OD023375NIH HHS UG3 OD023365NIH HHS UG3 OD035508NIH HHS UG3 OD035509NIH HHS UG3 OD035513NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035519NIH HHS UG3 OD035521NIH HHS UG3 OD035526NIH HHS UG3 OD035527NIH HHS UG3 OD035528NIH HHS UG3 OD035529NIH HHS UG3 OD035532NIH HHS UG3 OD035533NIH HHS UG3 OD035536NIH HHS UG3 OD035537NIH HHS UG3 OD035540NIH HHS UG3 OD035542NIH HHS UG3 OD035543NIH HHS UG3 OD035544NIH HHS UG3 OD035546NIH HHS UG3 OD035550NIH HHS UH3 OD023244NIH HHS UH3 OD023248NIH HHS UH3 OD023249NIH HHS UH3 OD023251NIH HHS UH3 OD023253NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023272NIH HHS UH3 OD023275NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023313NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023332NIH HHS UH3 OD023337NIH HHS UH3 OD023342NIH HHS UH3 OD023344NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIH HHS UH3 OD023389NIH HHS UH3 OD035509NIH HHS UH3 OD035518NIH HHS UH3 OD035519NIH HHS UH3 OD035521NIH HHS UH3 OD035528NIH HHS UH3 OD035529NIH HHS UH3 OD035533NIH HHS UH3 OD035536NIH HHS UH3 OD035542NIH HHS UH3 OD035543NIH HHS UH3 OD035546
6 · The paper itself

Abstract

Psychosocial stressors may exacerbate observed associations between environmental toxicants and adverse birth outcomes. However, studies have primarily focused on well-known compounds rather than a broader range of chemicals of concern. Pregnant women in this analysis had a prenatal urine sample analyzed for 113 well-studied and understudied chemical analytes, and at least one measure of psychosocial stress (N = 1566). We measured analytes from 10 chemical classes, including fungicides/herbicides, insecticides, halogenated phenols, organophosphorus flame retardants, benzophenones, bisphenols, parabens, antimicrobials, phthalates/alternative plasticizers, and polycyclic aromatic hydrocarbons. Principal component analysis was used to identify clusters of exposure patterns. Generalized Estimating Equation models assessed associations between principal components (PCs) and molar sums of each chemical class with birthweight z-scores and gestational age at birth, stratified by individual stressors (i.e., categorical adverse childhood experiences [ACEs; 0, 1-2, and 3-5]; binary prenatal perceived stress, depression, and anxiety). The PC reflecting higher exposure to all analytes (PC1) was negatively associated with birthweight z-scores only among those who experienced 3-5 ACEs compared with those with no ACEs (β

Indexed as

Environmental PollutantsMaternal ExposureStress, PsychologicalAdultBirth WeightCohort StudiesEnvironmental ExposureFemaleHumansInfant, NewbornPregnancyPregnancy OutcomeYoung AdultEnvironmental PollutantsBirthweightChemical exposureExposomeGestational agePregnancyPsychosocial stress

Identifiers

PMID41308729
PMCPMC12810359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.