ArticleJournal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation2026
Vegetarian Dietary Patterns and Diet-Related Metabolites Are Associated With Kidney Function in the Adventist Health Study-2 Cohort.
Article in Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Nutritional modulation of male fertility: a molecular-focused scoping review.Journal of health, population, and nutrition · 2026Article
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4 authors.
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Abstract
objectivesChronic kidney disease is a significant global health burden. Plant-based diets have shown potential benefits for kidney function, but the specific impacts of vegetarian dietary patterns and underlying metabolic mechanisms remain unclear.
methodsSerum creatinine was measured in 899 Adventist Health Study-2 cohort participants who were classified as vegan, lacto-ovo-vegetarian, pesco-vegetarian, semivegetarian, or nonvegetarian, and estimated glomerular filtration rate (eGFR) was calculated (<60 or >/ = 60 mL/min/1.73 m
resultsVegan and pesco-vegetarian dietary patterns were associated with significantly higher eGFR compared to nonvegetarians, with minimal attenuation after adjustment. Metabolomics analysis revealed distinct profiles in relation to creatinine, comparing the 90th to 10th percentiles. Creatinine was positively associated with several lipid and amino acid subclasses, which were lower in participants following vegetarian dietary patterns. Key subclasses included acetylated peptides, histidine metabolism, lysine metabolism, plasmalogens, and notably sphingomyelins for pesco-vegetarians. Individual metabolites within many of the differential subclasses consistently showed opposite directions of associations with vegetarian dietary patterns and creatinine.
conclusionsVegan and pesco-vegetarian dietary patterns, relative to nonvegetarian, were associated with higher eGFR, potentially through diet-driven metabolic pathways. Plant-based diets may offer protection against chronic kidney disease by modulating key metabolic pathways.
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