Evidence map›Paper›PMID 41308657›Full record

ArticleCell proliferation2026

Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma.

Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin and 7 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sicheng BianDepartment of Medicine, The MetroHealth System, Case Western Reserve University, Cleveland, USA.
Jiangxia CuiInstitute of Hematology, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Xialin ZhangDepartment of Hematology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Chongzhi BaiCentral Laboratory, Shanxi Province Hospital of Traditional Chinese Medicine, Taiyuan, China.
Yanhong TanInstitute of Hematology, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Zhuanghui HaoInstitute of Hematology, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Xingpeng BuDepartment of General Medicine, Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0003-0494-5450
Changxin QuDepartment of Preventive Medicine, The Second Hospital of Huairou, Beijing, China.
Lili SunDepartment of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
Leilei LinDepartment of Hematology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Qi WangShanghai Jiaotong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-5287-6050
Zhengrui LiShanghai Jiaotong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-4923-0088
Xufeng HuangShanghai Jiaotong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-9941-3355
Hengrui LiuDepartment of Biochemistry, Cambridge University, Cambridge, UK.ORCID https://orcid.org/0000-0002-5369-3926
Ruo WangShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.ORCID https://orcid.org/0000-0002-0676-5085
Yinghua LiDepartment of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.ORCID https://orcid.org/0000-0002-8060-8221
Hongwei WangInstitute of Hematology, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0002-2902-591X

Funding

Harbin Medical UniversityShanxi Provincial Natural Science Foundation of China 202203021221271Shanxi Provincial Natural Science Foundation of China 202203021222391
6 · The paper itself

Abstract

Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the loss of sialic acid coverage. Immunoglobulins in plasma adhere to RBC membrane Band3 extracellularly exposed peptides through intermolecular interactions. The reduction of sialic acid causes a weakening of the RBC membrane negative charge barrier and the adhesion of immunoglobulins further destabilises the suspension of RBCs, resulting in a rapid addition of ESR to multiple myeloma.

Indexed as

Anion Exchange Protein 1, ErythrocyteBlood SedimentationImmunoglobulinsMultiple MyelomaCell AdhesionErythrocyte MembraneErythrocytesHumansN-Acetylneuraminic AcidReactive Oxygen SpeciesAnion Exchange Protein 1, ErythrocyteImmunoglobulinsN-Acetylneuraminic AcidReactive Oxygen Species

Identifiers

PMID41308657
PMCPMC12961554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.