Evidence map›Paper›PMID 41308644›Full record

ArticleNeuron2026

Exploiting correlations across trials and behavioral sessions to improve neural decoding.

Yizi Zhang, Hanrui Lyu, Cole Hurwitz, Shuqi Wang, Charles Findling, Yanchen Wang, Felix Hubert, International Brain Laboratory, Alexandre Pouget, Erdem Varol and 1 more

Abstract read
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yizi ZhangDepartment of Statistics, Columbia University, New York, NY, USA. Electronic address: yz4123@columbia.edu.
Hanrui LyuDepartment of Statistics and Data Science, Northwestern University, Evanston, IL, USA.
Cole HurwitzCenter for Theoretical Neuroscience, Columbia University, New York, NY, USA; The International Brain Laboratory.
Shuqi WangDepartment of Computer Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Charles FindlingThe International Brain Laboratory; Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Yanchen WangCenter for Theoretical Neuroscience, Columbia University, New York, NY, USA.
Felix HubertDepartment of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
International Brain LaboratoryThe International Brain Laboratory.
Alexandre PougetThe International Brain Laboratory; Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
Erdem VarolDepartment of Computer Science and Engineering, New York University, New York, NY, USA.
Liam PaninskiDepartment of Statistics, Columbia University, New York, NY, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY, USA; The International Brain Laboratory. Electronic address: liam@stat.columbia.edu.

Funding

State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STEINMETZ, NICHOLAS · 2021 to 2025
$18.2M
Transcriptional basis of stereotyped neural architecturesR00MH128772 · NIMH · NEW YORK UNIVERSITY · PI Erdem Varol · 2024 to 2026
$734k
Transcriptional basis of stereotyped neural architecturesK99MH128772 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VAROL, ERDEM · 2022 to 2023
$251k
NIMH NIH HHS K99 MH128772NIMH NIH HHS R00 MH128772NINDS NIH HHS U19 NS123716Wellcome Trust
6 · The paper itself

Abstract

Traditional neural decoders link neural activity to behavior within single trials of a session, overlooking correlations across trials and sessions. However, animals show similar neural patterns when performing the same task, and their behaviors are influenced by prior experiences. To capture these dependencies, we introduce two complementary models: a multi-session reduced-rank regression model that shares behaviorally relevant neural structure across sessions and a multi-session state-space model that captures behavioral structure across trials and sessions. On 433 sessions spanning 270 brain regions in the International Brain Laboratory (IBL) mouse Neuropixels dataset, our decoders outperform traditional approaches on four behaviors, with results generalizing across datasets, species, and tasks. Unlike deep learning methods, our models are efficient and interpretable, providing low-dimensional neural representations, task-related single-neuron contributions, and brain-wide timescales of neural activation.

Indexed as

Behavior, AnimalBrainModels, NeurologicalNeuronsAnimalsMicedecision-makingelectrophysiologyinterpretable modelsmulti-session modelingneural decodingNeuropixels recordingsreduced-rank regressionstate-space models

Identifiers

PMID41308644
PMCPMC12695064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.