ArticleThe journal of nutrition, health & aging2026
Association Between Omega-3 Supplement Use and Cognitive Function in Korean Older Adults: An 8-Year Longitudinal Cohort Study.
Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesSouth Korea has a relatively high baseline omega-3 fatty acids (O3FA) status due to dietary patterns. However, evidence on additional benefits of O3FA supplementation remains limited. This study examined the 8-year longitudinal effects of O3FA supplement use on cognitive performance among community-dwelling older adults in South Korea.
designProspective longitudinal cohort study. SETTING AND
participantsData were from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). A total of 4,949 adults aged ≥60 years (mean age = 69.55 ± 6.56; 44.2% men) were included, and 2,053 completed the 8-year follow-up (2010-2012 to 2018-2020). MEASUREMENTS: O3FA supplement use was assessed through structured questionnaires on regular intake of omega-3 or fish oil supplements. Cognitive performance was assessed using the Korean version of Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet Neuropsychological Assessment Battery (CERAD-K[N]), and total and memory domain scores were analyzed. Longitudinal changes were examined using repeated measures analysis of covariance and linear mixed-effects models (LMMs; unweighted and weighted), adjusting for potential covariates.
resultsOver the 8 years, CERAD-K[N] (t = -2.686, p = .007) and memory domain (t = -4.026, p < .001) scores significantly improved among O3FA users. In the weighted LMM, significant time × supplement duration interactions were observed (CERAD-K[N]: β = 2.398, 95% CI 1.207-3.589, p < .001; memory: β = 1.050, 95% CI 0.643-1.456, p < .001), indicating greater improvement in long-term users.
conclusionO3FA supplement use was associated with better maintenance of cognitive function over eight years. These findings suggest a potential role of O3FA supplementation in supporting cognitive health during aging.
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