Evidence map›Paper›PMID 41308135›Full record

ArticleScience (New York, N.Y.)2025

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity.

Sung-Ya Lin, Hannah R Futeran, Briana N Cruga, Andrew Santiago-Frangos, Mia T Levine

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The long reach of the Red Queen.Nature reviews. Genetics · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sung-Ya LinDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0006-6268-4323
Hannah R FuteranDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0008-3163-9778
Briana N CrugaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2447-764X
Andrew Santiago-FrangosDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Mia T LevineDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4311-7535

Funding

Causes and functional consequences of chromatin evolutionR35GM124684 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Mia Tauna Levine · 2017 to 2026
$3.5M
Mechanisms of CRISPR-mediated immunity and applications beyond editingR00GM147842 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Andrew Santiago-Frangos · 2024 to 2026
$747k
NIGMS NIH HHS R00 GM147842NIGMS NIH HHS R35 GM124684
6 · The paper itself

Abstract

Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such complexes and threaten their essential functions remains unexplored. To investigate this, we exploited a

Indexed as

Chromosomal Proteins, Non-HistoneDrosophila melanogasterDrosophila ProteinsEvolution, MolecularMultiprotein ComplexesTelomereAnimalsFemaleMaleRetroelementscav protein, DrosophilaChromosomal Proteins, Non-HistoneDrosophila ProteinsMultiprotein ComplexesRetroelements

Identifiers

PMID41308135
PMCPMC12782124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.