Evidence map›Paper›PMID 41308071›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Endocrinology across the Lifespan.

Evelien F Gevers, Martine Cools, Anita C Hokken-Koelega, Yulia Matskevich, Aart Jan van der Lely, Mathis Grossmann, Gudmundur Johannsson

Abstract readReview
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evelien F GeversCentre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK, evelien.gevers@nhs.net.
Martine CoolsDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Anita C Hokken-KoelegaDepartment of Paediatrics, Erasmus University Medical Centre Rotterdam, Sophia Children's Hospital, Rotterdam, The Netherlands.
Yulia MatskevichEU Funding Consultant, Brussels, Belgium.
Aart Jan van der LelyDivision of Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Mathis GrossmannDepartment of Medicine, Austin Health/Northern Health, University of Melbourne, Heidelberg, Victoria, Australia.
Gudmundur JohannssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains under-represented in European Union (EU) research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At the national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database focusing the Horizon 2020 framework period (2014-2020). Expert analysis examined endocrine regulation and health from gametogenesis through embryonic development, early life, puberty, adulthood, and aging, integrating evidence across developmental stages.

resultsResearch priorities encompass understanding epigenetic programming from embryonic life; elucidating developmental origins of adult disease; investigating brain-gut communication across ages; and addressing endocrine aspects of healthy aging. Special emphasis is placed on critical developmental windows, transgenerational effects, and the need for integrated research approaches spanning paediatric and adult endocrinology.

conclusionsThis component of the EndoCompass project provides an evidence-based roadmap for understanding hormone regulation across life stages. The analysis demonstrates the need for coordinated research spanning conception to aging to address Europe's demographic challenges. The findings support strategic investment in lifespan approaches to endocrine health.

Indexed as

Databases, FactualEndocrine System DiseasesEndocrinologyAdolescentAdultChildChild, PreschoolEuropean UnionFemaleHumansMaleAgingEndoCompassLifespanRoadmap

Identifiers

PMID41308071
PMCPMC12698123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.