Evidence map›Paper›PMID 41308051›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology.

Justo P Castano, Mehul Tulsidas Dattani, Simona Grozinsky-Glasberg, Niki Karavitaki, Marianne E Pavel, Cynthia Andoniadou, Krystallenia Alexandraki, Cristina Capatina, Manuela Cerbone, Diego Ferone and 17 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Justo P CastanoDepartment of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.
Mehul Tulsidas DattaniGenetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London, UK.
Simona Grozinsky-GlasbergNeuroendocrine Tumor Unit, ENETS Centre of Excellence, Division of Medicine, Hadassah University Hospital and Faculty of Medicine, The Hebrew University, Jerusalem, Israel, simonag@hadassah.org.il.
Niki KaravitakiInstitute of Metabolism and Systems Research, University of Birmingham, and Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Marianne E PavelMedizinische Klinik 1, Schwerpunkt Endokrinologie und Diabetologie, Uniklinikum Erlangen, ENETS Center of Excellence Erlangen, CCC Erlangen-EMN, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Cynthia AndoniadouFaculty of Medicine Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, Dresden, Germany.
Krystallenia Alexandraki2nd Department of Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Cristina CapatinaDepartment of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Manuela CerboneGenetics and Genomic Medicine Research and Teaching Department, Great Ormond Street Hospital for Children, London, UK.
Diego FeroneEndocrinology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Hoong-Wei GanDepartment of Endocrinology, Great Ormond Street Hospital for Children, London, UK.
Johannes HoflandENETS Center of Excellence, Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Leo HoflandENETS Center of Excellence, Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Alejandro Ibanez-CostaDepartment of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.
Mirela-Diana IlieInserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France.
Andrea M IsidoriSection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Marta KorbonitsDepartment of Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Beata Kos-KudłaDepartment of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.
Mohamad MaghniePediatric Clinic and Endocrinology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy.
Giovanna MantovaniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Monica MarazuelaUniversidad Autónoma de Madrid, Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Madrid, Spain.
Gerald RaverotEndocrinology Department, Hospices Civils de Lyon, Reference Centre for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est,", Bron, France.
Aldo ScarpaDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
Katharina SchilbachMedizinische Klinik and Poliklinik IV, LMU Klinikum München, Munich, Germany.
Marily TheodoropoulouDepartment of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.
Hanneke M van SantenDivision of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.
Maria Chiara ZatelliSection of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

resultsResearch priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases.

conclusionsThis component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Indexed as

Biomedical ResearchEndocrinologyNeuroendocrine TumorsPituitary NeoplasmsDatabases, FactualHumansEndoCompassFundingRoadmapThyroid

Identifiers

PMID41308051
PMCPMC12698125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.