Evidence map›Paper›PMID 41307755›Full record

ReviewCurrent pain and headache reports2025

The Mechanism of Action of Remote Electrical Neuromodulation (REN) in Treating Migraine and Potentially Other Idiopathic Pain Conditions.

Marius Birlea, Christopher L Robinson, Eden Mama, Alit Stark-Inbar, Alon Ironi, Daniel Atashsokhan, Thomas Berk

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marius BirleaUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-4663-2084
Christopher L RobinsonDivision of Pain Medicine, Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6276-9056
Eden MamaTheranica, Netanya, Israel.ORCID http://orcid.org/0009-0000-5076-7427
Alit Stark-InbarTheranica, Netanya, Israel.ORCID http://orcid.org/0000-0001-6434-6447
Alon IroniTheranica, Netanya, Israel.ORCID http://orcid.org/0000-0002-3992-4978
Daniel AtashsokhanYale School of Medicine, New Haven, Connecticut, USA.ORCID http://orcid.org/0009-0005-9747-7773
Thomas BerkNeura Health, Thomas Jefferson University, Philadelphia, USA. tom@neurahealth.co.ORCID http://orcid.org/0000-0002-8383-8444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review provides evidence for the mechanism of action (MOA) of Remote Electrical Neuromodulation (REN), a non-pharmacological therapeutic technology for treating migraine and other symptoms manifested by certain idiopathic pain diseases. It discusses the main physiological and anatomical aspects associated with conditioned pain modulation (CPM), and how REN is applied for the treatment of migraine pain and other symptoms. RECENT

findingsThe REN wearable device (Nerivio

Indexed as

Electric Stimulation TherapyMigraine DisordersPain ManagementHumansWearable Electronic DevicesConditioned pain modulationIdiopathic painMechanism of actionMigrainePain inhibitionRemote electrical neuromodulation

Identifiers

PMID41307755
PMCPMC12660337

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.