Association of Serum Biomarkers with Outcomes and Treatment Success of Inhaled Hyaluronan in COVID19.

Jane S Der, Claudio Pedone, Flavia Galdi, Christopher A McGee, Raffaele Antonelli Incalzi, Stavros Garantziotis

Abstract read

In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jane S DerDLH Corp., LLC, Bethesda, MD, USA.

Claudio PedoneOperative Research Unit of Geriatrics, Fondazione Policlinico Campus Bio-Medico, and Research Unit of Geriatrics, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Flavia GaldiOperative Research Unit of Internal Medicine, Fondazione Policlinico Campus Bio-Medico, Rome, IT, Italy.

Christopher A McGeeDivision of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Raffaele Antonelli IncalziOperative Research Unit of Internal Medicine, Fondazione Policlinico Campus Bio-Medico, Rome, IT, Italy.

Stavros GarantziotisDivision of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. garantziotis@niehs.nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral pneumonia causes significant morbidity and mortality worldwide. However, there is limited ability to predict outcomes and treatment responses. We analyzed data from a recently published placebo-controlled trial of inhaled high molecular weight hyaluronan (HMWHA) in 146 patients with severe COVID-19 pneumonia, to determine whether admission cytokines and demographic information is associated with disease outcomes and response to HMWHA treatment. We found that serum levels of CXCL10 are strongly associated with both endpoints. Our data thus identify CXCL10 as a possible predictor of viral pneumonia outcome and response to anti-inflammatory treatment.

Indexed as

Chemokine CXCL10COVID-19 Drug TreatmentHyaluronic AcidAdministration, InhalationAgedBiomarkersCOVID-19FemaleHumansMaleMiddle AgedSARS-CoV-2Treatment OutcomeBiomarkersChemokine CXCL10CXCL10 protein, humanHyaluronic AcidCXCL10HyaluronanOutcomesViral pneumonia

Identifiers

PMID41307734

DOI10.1007/s00408-025-00858-8

PMCPMC12660381

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.