The Potential Implications of Neutrophil to Albumin Ratio for Short-term Prognosis in Myasthenia Gravis Patients.

Studies have shown that inflammation plays an important role in the pathogenesis of Myasthenia gravis (MG). The neutrophil to albumin ratio (NAR) stands out as a novel inflammatory biomarker; however, its relationship with MG has not been explored. This study aims to investigate the ability of NAR to monitor disease severity and predict the short-term prognosis in patients with MG. This retrospective study included 134 patients with MG. Multivariate regression and subgroup analyses were used to comprehensively explore the association between NAR and short-term prognoses. A prediction model was then built and visualized using a nomogram. Three approaches were used to evaluate the performance of the proposed nomogram. The NAR was significantly higher in patients with more severe disease conditions at baseline (p < 0.001). After adjusting for confounding factors, NAR was still independently associated with short-term prognosis of patients with MG (OR = 5.376, 95%CI = 1.321-21.881, p = 0.019). Prehospital infection, thymectomy, Myasthenia Gravis Foundation of America classification and NAR were included to establish the final short-term prognosis prediction model. The good performance of the model was verified by the receiver operating characteristic curve (AUC = 0.782, p < 0.05), calibration curve (chi-square = 8.492, p = 0.387) and decision curve analysis plot. Our study found that NAR can effectively monitor disease severity in patients with MG and is independently associated with short-term prognosis. The nomogram visualizes the prediction model and is beneficial for clinical application.