Evidence map›Paper›PMID 41307581›Full record

ReviewDer Nervenarzt2026

What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393.

Elisabeth J Leehr, Joachim Groß, Stefan G Hofmann, Philipp Kanske, Tilo Kircher, Igor Nenadić, Winfried Rief, Philipp Ritter, Allan Young, Katharina Förster

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Der Nervenarzt, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Albert-Schweitzer-Campus 1, Building A9, 48149, Münster, Germany. leehr@uni-muenster.de.
Joachim GroßInstitute for Biomagnetism and Biosignal Analyses, University of Münster, Münster, Germany.
Stefan G HofmannDepartment of Psychology, Philipps-Universität Marburg, Marburg, Germany.
Philipp KanskeInstitute of Clinical Psychology and Psychotherapy, TUD Dresden University of Technology, Dresden, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Universität Marburg, Marburg, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Universität Marburg, Marburg, Germany.
Winfried RiefDepartment of Psychology, Philipps-Universität Marburg, Marburg, Germany.
Philipp RitterDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Allan YoungDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Katharina FörsterInstitute of Clinical Psychology and Psychotherapy, TUD Dresden University of Technology, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAffective disorders are associated with an enormous disease burden, necessitating research on the mechanisms of effective treatments.

objectivesThis article introduces the intervention projects of the transregional Collaborative Research Center 393 (CRC/TRR 393). By employing targeted interventions, we aim to induce modifiability in the key mechanisms underlying the trajectories of affective disorders studied in CRC/TRR 393: emotion regulation, expectation, social cognition, and (circadian) cognitive-behavioral rhythms. MATERIALS AND

methodsThe longitudinal design of the CRC/TRR 393 study will examine four interventions targeting specific mechanisms in subgroups of the German Mental Health Cohort (GEMCO). GEMCO includes patients with a current or lifetime diagnosis of major depressive disorder (MDD), bipolar disorder (BD), and healthy control (HC) participants. Multilevel measurements of these targeted mechanisms will allow us to investigate their fine-grained modifiability and their effects on disease trajectories.

resultsThe results will provide insights into how these mechanisms can be modified. Together with the CRC/TRR 393 mechanisms projects, we will examine the effects of key cognitive-emotional mechanisms on disease trajectories.

conclusionFor the first time, the modifiability of four key mechanisms underlying the trajectories of affective disorders will be investigated both cross-sectionally and longitudinally.

Indexed as

Bipolar DisorderMajor Depressive DisorderMood DisordersAdultCross-Sectional StudiesEmotional RegulationFemaleGermanyHumansLongitudinal StudiesMaleAffective disorders, emotion regulationCircadian rhythmEmpathyExpectation violationMood disorders

Identifiers

PMID41307581
PMCPMC12953325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.